alexa Mechanisms of Radiation Resistance in Deinococcus radiodurans R1 Revealed by the Reconstruction of Gene Regulatory Network Using Bayesian Network Approach
ISSN: 0974-276X

Journal of Proteomics & Bioinformatics
Open Access

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Research Article

Mechanisms of Radiation Resistance in Deinococcus radiodurans R1 Revealed by the Reconstruction of Gene Regulatory Network Using Bayesian Network Approach

Ping Wan1#*, Zongliang Yue1#, Zhan Xie1#, Qiang Gao1, Mengyao Yu1, Zhiwei Yang1 and Jinsong Huang2*

1College of Life Science, Capital Normal University, Beijing, 100048, China

2Beijing Computing Center, Beijing, 100094, China

#Contributed equally

*Corresponding Author:
Ping Wan
College of Life Science
Capital Normal, University
Beijing, 100048, China
E-mail: [email protected]

Jinsong Huang
Beijing Computing Center
Beijing, 100094, China
E-mail: [email protected]

Received Date: May 22, 2013; Accepted Date: June 24, 2013; Published Date: June 27, 2013

Citation: Wan P, Yue Z, Xie Z, Gao Q, Yu M, et al. (2013) Mechanisms of Radiation Resistance in Deinococcus radiodurans R1 Revealed by the Reconstruction of Gene Regulatory Network Using Bayesian Network Approach. J Proteomics Bioinform S6: 007. doi: 10.4172/jpb.S6-007

Copyright: © 2013 Wan P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The mechanisms of radiation resistance in the extreme anti-radiation bacterium Deinococcus radiodurans R1 have fascinated researchers for more than sixty years. In this study, with the DNA microarray data, we first constructed the gene regulatory network in D. radiodurans R1 using Bayesian network approach. The results of our analysis for the gene regulatory network reveal twelve significant mechanisms of radiation resistance in D. radiodurans R1, of which two mechanisms (DNA repair and reactive oxygen species) are consistent with the wellknown knowledge; and two mechanisms (metal ion homeostasis and oxygen transport process) support Daly’s manganese-based radiation protection hypothesis. We also demonstrate that different mechanisms act in concert under the radiation stress in D. radiodurans R1.

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