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Melanotic Neurofibroma: A Case Report | OMICS International | Abstract
ISSN: 2165-7920

Journal of Clinical Case Reports
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Case Report

Melanotic Neurofibroma: A Case Report

Elousrouti LT*, Erreggad FZ, Ebang GA, Efared B, Sory I, Hammas N, Chbani L, Elfatemi H and Harmouch T

Department of Pathology, University Hospital of Hassan II, Fez, Morocco

*Corresponding Author:
Elousrouti LT
Department of Pathology
University Hospital of Hassan II
Fez, Morocco
Tel: +212 5356-19053
E-mail: [email protected]

Received date: March 08, 2016; Accepted date: May 11, 2016; Published date: May 17, 2016

Citation: Elousrouti LT, Erreggad FZ, Ebang GA, Efared B, Sory I, et al. (2016) Melanotic Neurofibroma: A Case Report. J Clin Case Rep 6: 804. doi:0.4172/2165-7920.1000804

Copyright: © 2016 Elousrouti LT, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Introduction: Melanotic neurofibromas are rare tumours, derived from peripheral nerve sheath, whose originality consists in the presence of melanic pigment. The clinical and histological diagnosis is often difficult to make requiring the immunohistochemical exam to make the difference between melanotic neurofibroma and the other pigmented tumors. Melanotic neurofibroma has a good prognosis and the malignization is rare. Case Report: A 22 year-old man presented since childhood a left occipital tumor, it had a firm consistency and pigmented color. CT objectified isodense occipital mass, which enhanced heterogeneously after contrast product. Lack of bone loss beside. Complete surgical excision was performed. Histological and immunohistochemical analysis led to the diagnosis of melanotic neurofibroma. Discussion: Pigmented neurofibroma is a rare variant of neurofibroma showing melanin production and constitute less than 1% of all cases. It can occur on their own or be associated with neurofibromatosis. They must be distinguished from classical neurofibromas when pigmentation occurs in the latter. Melanotic neurofibromas usually appear in the second or third decade of life and rarely in childhood. The clinical diagnosis is difficult to establish requiring the histopathological examination to differentiate between the melanotic neurofibroma and other pigmented tumours. It can mimicking a giant naevus or a neurocristic cutaneous hamartoma. These are the two main differential diagnoses among children. Among adults, the main difficulty is to distinguish melanotic neurofibroma from pigmented dermatofibrosarcoma. The elective treatment is surgical, represented by the complete excision of the tumor. Conclusion: Pigmented neurofibroma is a unique subtype of neurofibroma which is rare and contains melanin producing cells. The histopathological features with unique pattern of melanogenesis, ultrastructural findings and immunohistochemistry will enable us to diagnose this entity and differentiate it from other pigmented tumours of skin.


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