Melatonin in Surgery and Critical Care Medicine
- *Corresponding Author:
- Lars Peter Holst Andersen
Department of Surgery D, Herlev Hospital
University of Copenhagen, DK-2730 Herlev, Denmark
Tel: +45 31518908
Fax: +45 38683602
E-mail: [email protected]
Received Date: April 11, 2014; Accepted Date: May 20, 2014; Published Date: May 22, 2014
Citation: Andersen LPH, Werner MU, Rosenberg J, Gögenur I (2014) Melatonin in Surgery and Critical Care Medicine. J Anesth Clin Res 5:407. doi: 10.4172/2155-6148.1000407
Copyright: © 2014 Holst Andersen LP. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Administration of exogenous melatonin in surgical and critical care patients has been investigated for various clinical purposes. Studies have demonstrated that melatonin can be used for treatment of preoperative anxiety. The analgesic effect of melatonin is well documented in experimental studies, but still needs to be established further in human clinical studies. The sleep-regulating effects of melatonin in surgical and critical care patients remain unclear. Melatonin has been shown to reduce emergence delirium in the early postoperative period, but no evidence exists in relation to postoperative and intensive care delirium. Limited evidence exists with respect to reduction of oxidative stress in surgical patients. Melatonin has been shown to improve outcome in experimental sepsis models, but still needs to be documented further in human clinical studies. Mechanisms of actions need to be clarified and most importantly dose-response relationships should to be established within the specific procedures and indications. Finally, paramount issues remain in relation to administration form, dosage, timing of administration, and pharmacokinetics of melatonin in surgical and critical care patients.