alexa Membrane Flexibility and Exercise: A Guide to Type 2 Diabetes Mellitus | OMICS International | Abstract
ISSN: 2155-6156

Journal of Diabetes & Metabolism
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Review Article

Membrane Flexibility and Exercise: A Guide to Type 2 Diabetes Mellitus

Rob Weijers*

Teaching Hospital, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands

*Corresponding Author:
Rob Weijers
Onze Lieve Vrouwe Gasthuis
Oosterparkstraat 9
PO Box Box 95500
1090 HM Amsterdam
The Netherlands
Tel: +31-30-6362637
E-mail: [email protected]

Received date January 03, 2013; Accepted date February 18, 2013; Published date February 23, 2013

Citation: Weijers R (2013) Membrane Flexibility and Exercise: A Guide to Type 2 Diabetes Mellitus. J Diabetes Metab S10:003. doi:10.4172/2155-6156.S10-003

Copyright: © 2013 Weijers R. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


During the last two decades the discipline of biology developed the pacemaker hypothesis, which notes that the molecular composition of the mammalian lipid bilayer is centrally involved in regulating the metabolic activity of cells. At the same time, the discipline of physical chemistry demonstrated that the ratio of unsaturated to saturated fatty acyl chains regulates the mutual distance of these chains in a bilayer membrane, and consequently affects the flexibility of the membrane. Based on these innovative results, an assessment of the deformability of the red blood cell provides reliable information about glucose disposal during the treatment of type 2 diabetes mellitus, as well as during aerobic exercise.


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