Meningeal Infiltration of Chronic Myelomonocytic LeukemiaInga Mandac Rogulj*, Slobodanka Ostojic Kolonic, Delfa Radic Kristo and Ana Planinc-Peraica
Department of Hematology, Clinical Hospital Merkur, Croatia
- *Corresponding Author:
- Inga Mandac Rogulj
Department of Hematology
Clinical Hospital Merkur
Zajceva Street 19, 10 000 Zagreb, Croatia
Email: [email protected]
Received date: July 13, 2014; Accepted date: August 20, 2014; Published date: August 26, 2014
Citation: Rogulj IM, Kolonic SO, Kristo DR, Planinc-Peraica A (2014) Meningeal Infiltration of Chronic Myelomonocytic Leukemia. J Leuk (Los Angel) 2:147. doi: 10.4172/2329-6917.1000147
Copyright: © 2014 Inga Mandac Rogulj, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Chronic Myelomonocytic Leukemia (CMML) is a hematologic malignancy considered a subtype of Myelodysplastic Syndrome (MDS)/Myeloproliferative Disease (MPD). According the World Health Organization (WHO) two subtypes of CMML, CMML-1 and CMML-2 are defined depending on the percentage of blasts in Bone Marrow (BM) and Peripheral Blood (PB). The clinical presentation is variable, but the majority of patients present with fatigue, weight loss, fever, night sweats and splenomegaly, less often skin infiltration or serous effusions. Meningeal leukemic involvement is rarely a presenting feature of CMML. We are reporting a case of 67-year old male with central nervous system involvement of CMML.