Mesenchymal Stem Cells as Muscle ReservoirMeregalli M, Farini A and Torrente Y*
Stem Cell Laboratory, Department of Neurological Sciences, Università degli Studi di Milano, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico di Milano, Centro Dino Ferrari, via F. Sforza, 35 20122 Milan, Italy
- *Corresponding Author:
- Dr. Torrente Yvan
Department of Neurological Sciences
Università degli Studi di Milano
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico di Milano
Centro Dino Ferrari, via Francesco Sforza 35, 20122 Milan, Italy
E-mail: [email protected]
Received date: March 28, 2011; Accepted date: July 11, 2011; Published date: July 14, 2011
Citation: Meregalli M, Farini A, Torrente Y (2011) Mesenchymal Stem Cells as Muscle Reservoir. J Stem Cell Res Ther 1:105. doi:10.4172/2157-7633.1000105
Copyright: © 2011 Meregalli M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Stem cell therapy is an attractive method to treat muscular dystrophy because only a small number of cells, together with a stimulatory signal for expansion, are required to obtain a therapeutic effect. Recently, it was published the isolation of human MSC-like cells from adult skeletal muscle. The aim of this review is to describe the recent progress in understanding MSC biology and their therapeutic applications. Given that these cells can be obtained with non- or minimally invasive-biopsy procedures, there is growing evidence that skeletal muscle may be an important clinical source of MSCs for use in therapeutic applications. Various in vitro and in vivo studies have evaluated the safety, feasibility and efficacy of transplanting MSCs for clinical trials. Currently, there are many registered clinical trial sites for evaluating MSC therapy throughout the world.