alexa Mesenchymal Stem Cells: Pivotal Players in Hematopoietic Stem Cell Microenvironment
ISSN: 2157-7633

Journal of Stem Cell Research & Therapy
Open Access

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Review Article

Mesenchymal Stem Cells: Pivotal Players in Hematopoietic Stem Cell Microenvironment

Sanaa EL Marsafy1*, Jérôme Larghero2-4, Annelise Bennaceur-Griscelli1,5,6 and Ali Turhan1,5,6

1Assistance Publique-Hôpitaux de Paris. Hôpital Paul Brousse, Laboratoire d’ Hematologie Biologique. Villejuif, France

2Assistance Publique –Hôpitaux de Paris, Hôpital Saint-Louis, Cell therapy Unit and Clinical Investigation Center (CIC) 1427, Paris, France

3University Paris Diderot, Sorbonne Paris Cité, F-75475 Paris, France

4INSERM UMR1160, Institute Universitaire d’Hématologie. Hôpital Saint-Louis, Paris France

5INSERM UMR 935, « ESteam Paris Sud », Stem cell core facility, Institute André Lwoff, University Paris Sud, Paul Brousse Hospital, Villejuif, France

6University Paris Sud11, Faculty of Medicine, Kremlin-Bicêtre, France

*Corresponding Author:
Sanaa EL Marsafy, MD, PhD
Assistance Publique – Hôpitaux de Paris, Hôpital Paul Brousse
Laboratoire d’Hematologie Biologique, Villejuif, France
Tel: +33 1 42 49 96
E-mail: [email protected]

Received date: July 04, 2014; Accepted date: August 05, 2014; Published date: August 07, 2014

Citation: EL Marsafy S, Larghero J, Bennaceur-Griscelli A, Turhan A (2014) Mesenchymal Stem Cells: Pivotal Players in Hematopoietic Stem Cell Microenvironment. J Stem Cell Res Ther 4:225. doi:10.4172/2157-7633.1000225

Copyright: © 2014 El Marsafy S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The hematopoietic stem cells (HSC) reside in a specialized microenvironment in the bone marrow (BM) referred to as the osteoblastic and perivascular niches where various components involving the mesenchymal stem cells (MSC) and their progeny are implicated in shaping the HSC compartment. Of interest, the development of various disorders including leukemia, cancers and autoimmune diseases are associated with abrasions and altered functions of MSC. Herein, we focus attention on the subtypes of MSC in the HSC niche with emphasis on their role in controlling normal and malignant hematopoiesis. Additionally, MSC therapeutic potential in targeting tumor cells will be discussed. Delineation of the cross-talk between MSC and HSC is valuable for a better comprehension of the underlying physiopathology of a given hematologic disorder and might pave the way for new therapeutic approaches.


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