Mesenchymal Stem Cells: Pivotal Players in Hematopoietic Stem Cell MicroenvironmentSanaa EL Marsafy1*, Jérôme Larghero2-4, Annelise Bennaceur-Griscelli1,5,6 and Ali Turhan1,5,6
- *Corresponding Author:
- Sanaa EL Marsafy, MD, PhD
Assistance Publique – Hôpitaux de Paris, Hôpital Paul Brousse
Laboratoire d’Hematologie Biologique, Villejuif, France
Tel: +33 1 42 49 96
E-mail: [email protected]
Received date: July 04, 2014; Accepted date: August 05, 2014; Published date: August 07, 2014
Citation: EL Marsafy S, Larghero J, Bennaceur-Griscelli A, Turhan A (2014) Mesenchymal Stem Cells: Pivotal Players in Hematopoietic Stem Cell Microenvironment. J Stem Cell Res Ther 4:225. doi:10.4172/2157-7633.1000225
Copyright: © 2014 El Marsafy S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The hematopoietic stem cells (HSC) reside in a specialized microenvironment in the bone marrow (BM) referred to as the osteoblastic and perivascular niches where various components involving the mesenchymal stem cells (MSC) and their progeny are implicated in shaping the HSC compartment. Of interest, the development of various disorders including leukemia, cancers and autoimmune diseases are associated with abrasions and altered functions of MSC. Herein, we focus attention on the subtypes of MSC in the HSC niche with emphasis on their role in controlling normal and malignant hematopoiesis. Additionally, MSC therapeutic potential in targeting tumor cells will be discussed. Delineation of the cross-talk between MSC and HSC is valuable for a better comprehension of the underlying physiopathology of a given hematologic disorder and might pave the way for new therapeutic approaches.