Mesenchymal Stromal Cells and FibroblastsChristine Ulrich1, Melanie L. Hart1,2, Bernd Rolauffs3, Harald Abele4, Marco Götze5, Karin Benz6 and Wilhelm K Aicher1,5*
- Corresponding Author:
- Dr. Wilhelm K Aicher
Center for Regenerative Medicine
Deptarment of Orthopeadic Surg.ZMF
University of TübingenWaldhörnlstr. 2272072 Tübingen, Germany
Tel: +49 7071 29 86045
Fax: +49 7071 29 4637
E-mail: [email protected]
Received date: December 23, 2011; Accepted date: January 23, 2012; Published date: January 25, 2012
Citation: Ulrich C, Hart ML, Rolauffs B, Abele H, Götze M, et al. (2012) Mesenchymal Stromal Cells and Fibroblasts. J Tissue Sci Eng 3:e109. doi:10.4172/2157-7552.1000e109
Copyright: © 2012 Ulrich C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Adult mesenchymal stromal cells (MSC), also referred to as mesenchymal stem cells, were detected almost half a century ago in bone marrow and have been studied intensively in the last decade. Different aspects of MSC biology were explored and published. Studies pointed to their localization in different organs during development and in adulthood and described their characteristics in experimental or clinical investigations. Despite intensive research in the field and in sharp contrast to hematopoietic stem cells (HSC), it has become more and more clear that MSC lack a unique cell surface marker. MSC not only share cell surface markers with other types of cells, they also share many features with pericytes and fibroblasts, including their capability to differentiate into, for instance, osteoblasts or adipocytes. In this review we therefore screen the current literature to disclose differences between MSC and fibroblasts and also report on common qualities.