alexa Mesoporous Silica Nanospheres Functionalized by Tio2 as a Photoactive Antibacterial Agent
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

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Research Article

Mesoporous Silica Nanospheres Functionalized by Tio2 as a Photoactive Antibacterial Agent

Krzysztof Cendrowski1, Magdalena Peruzynska3, Agata Markowska-Szczupak2, Xuecheng Chen1, Anna Wajda3, Joanna Lapczuk3, Mateusz Kurzawski3, Ryszard J. Kalenczuk1, Marek Drozdzik3 and Ewa Mijowska1*

1West Pomeranian University of Technology Szczecin, Centre of Knowledge Based Nanomaterials and Technologies, Institute of Chemical and Environment Engineering, Poland

2West Pomeranian University of Technology Szczecin, Department of Biotechnology, Poland

3Pomeranian Medical University, Department of Pharmacology, Poland

*Corresponding Author:
Ewa Mijowska
West Pomeranian University of Technology Szczecin
Centre of Knowledge Based Nanomaterials and Technologies
Institute of Chemical and Environment Engineering
Pulaskiego street 10, Szczecin 70-322, Poland
Tel: (+48 91) 449 46 56
Fax: (+48 91) 449 46 86
E-mail: [email protected]

Received Date: October 24, 2013; Accepted Date: November 26, 2013; Published Date: November 28, 2013

Citation: Cendrowski K, Peruzynska M, Markowska-Szczupak A, Chen X, Wajda A, et al. (2013) Mesoporous Silica Nanospheres Functionalized by Tio2 as a Photoactive Antibacterial Agent. J Nanomed Nanotechnol 4:182. doi:10.4172/2157-7439.1000182

Copyright: © 2013 Cendrowski K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

In this contribution we present comparative study on synthesis, bio-characterization and antibacterial properties of mesoporous silica nanospheres modified by titanium dioxide. Mesoporous silica nanospheres functionalized by titania were studied as light activated antibacterial agents. The analysis of the antibacterial effects on E. coli ATCC 25922 shows strong enhancement during the visible and ultraviolet light irradiation in respect to the commercial catalyst and sample free from the nanomaterials. In darkness the mesoporous silica/titania nanostructures revealed low antibacterial activity dependent on the stirring intensity of the suspension containing nanomaterials and bacteria. The nanomaterials toxicity was determined on the amount of lactate dehydrogenase released from mouse fibroblast cells L929 with LDH assay. Sample was characterized in details by means of high resolution transmission electron microscopy (HR-TEM), Raman spectroscopy, XRD and BET Isotherm.

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