alexa Meta-analysis of CXCR7 Expression Related to Clinical Prognosis in Cancers | OMICS International | Abstract
ISSN: 2329-6771

Journal of Integrative Oncology
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Research Article

Meta-analysis of CXCR7 Expression Related to Clinical Prognosis in Cancers

Qian Cheng1, Yingfeng Wen4, Zhirong Sun1, Yanyan Zhang2, Xiaoxiao Qian3, Jianguo Wu5, Changhong Miao1* and Dongsheng Xu2,5*

1Department of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, 200032, P. R. China

2Center for Neuroimmunology and Regenerative Therapy, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, 200072, P. R. China

3University of Nebraska Medical Center School of Medicine, Omaha, NE 68198, USA

4Department of Neurology, Shanghai Minhang District Central Hospital, Shanghai, 201199, P. R. China

5State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, P. R. China

Corresponding Author:
Dongsheng Xu
Center for Neuroimmunology and Regenerative Therapy
Shanghai Tenth People’s Hospital
Tongji University School of Medicine
P. R. China
Tel: 402-559-3797
E-mail: [email protected]

Changhong Miao
Department of Anesthesiology
Fudan University Shanghai Cancer Center
Shanghai Medical College
Fudan University
P. R. China
Tel: 402-559-3797
E-mail: [email protected]

Received date: March 13, 2016; Accepted date: March 30, 2016; Published date: April 06, 2016

Citation: Cheng Q, Wen Y, Sun Z, Zhang Y, Qian X, et al. (2016) Meta-analysis of CXCR7 Expression Related to Clinical Prognosis in Cancers. J Integr Oncol 5:163. doi:10.4172/2329-6771.1000163

Copyright: © 2016 Cheng Q, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Purpose: Recently, higher expression of chemokine receptors in patients with various cancer types has been observed and indicated to have prognostic significance in the clinical progression of cancers. Former research has determined that CXCR7, as a member of chemokine receptor C-X-C family, empowers greater affinity with chemokine CXCL12 than CXCR4. The present study investigated the correlation of clinical characteristics and CXCR7 expression in cancers using meta-analysis. Methods: A comprehensive search on Pubmed and Web of Science identified CXCR7-related clinical studies. Methodological quality of these studies was evaluated and all the data were extracted, calculated and analyzed. This meta-analysis was carried out with Stata 12.0. Results: Fifteen eligible studies consisting of 1780 participants were included. The results showed that CXCR7 significantly relates to tumor occurrence (pooled RR=3.12, 95% CI: 1.71-5.70, P=0.000), tumor grades (pooled RR=1.41, 95% CI: 1.14-1.75, P=0.002), tumor stages (pooled RR=1.51, 95% CI: 1.26-1.82, P=0.000) and lymph node metastasis (pooled RR=1.49, 95% CI: 1.14-1.94, P=0.000), respectively. Conclusion: Highly expressed chemokine receptor CXCR7 potentially increases tumor occurrence risk. Higher CXCR7 expression is associated with poorer prognosis, advanced stages, differentiation grades and poor lymph node metastasis in patients with various cancers. Thus, highly expressed CXCR7 could be a potential biomarker in the prognosis of cancers.

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