alexa Metabolic Bone Disease of Prematurity: A Review of Minerals Supplementation and Disease Monitoring
ISSN: 2167-0897

Journal of Neonatal Biology
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Metabolic Bone Disease of Prematurity: A Review of Minerals Supplementation and Disease Monitoring

Valeria Anna Manfredini1*, Chiara Cerini2, Chiara Giovanettoni1, Emanuela Alice Brazzoduro1 and Rossano Massimo Rezzonico1
1Neonatal intensive care Unit, “G. Salvini” Hospital, RHO, Milan, Italy
2Division of Infectious Diseases, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, USA
Corresponding Author : Valeria Anna Manfredini, MD
Corso Europa 250, 20017, RHO (Milano), Italy
Tel: +39-02-994303261
Fax: +39-02-994303019
E-mail: [email protected]
Received: July 13, 2015 Accepted: August 5, 2015 Published: August 10, 2015
Citation: Manfredini VA, Cerini C, Giovanettoni C, Brazzoduro EA, Rezzonico RM (2015) Metabolic Bone Disease of Prematurity: A Review of Minerals Supplementation and Disease Monitoring. J Neonatal Biol 2015 4:187. doi:10.4172/2167-0897.1000187
Copyright: © 2015 Manfredini VA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Metabolic bone disease is a frequent condition in very low birth weight (VLBW) infants In order to prevent the disease, the provision of high amount of calcium and phosphate in parenteral nutrition solutions and during transition to the full enteral feedings is crucial. Current practice supports early aggressive mineral supplementation. In this review, we will discuss data from the recent literature regarding the recommendation for supplementation of calcium, phosphate and vitamin D in VLBW infants and the interpretation of indirect markers of bone metabolism for screening, diagnosis and monitoring high risk infants, as well as to guide treatment.

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