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Metabolic Control of Th17 Cell Generation and CNS Inflammation | OMICS International | Abstract
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
Open Access

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Special Issue Article

Metabolic Control of Th17 Cell Generation and CNS Inflammation

Kai Yang and Hongbo Chi*

Department of Immunology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA

Corresponding Author:
Hongbo Chi
Department of Immunology
St. Jude Children’s Research Hospital
Memphis, TN 38105, USA
Tel: 901-595-6282
Fax: 901-595-5766
E-mail: [email protected]

Received date: January 08, 2014; Accepted date: January 24, 2014; Published date: February 05, 2014

Citation: Yang K, Chi H (2014) Metabolic Control of Th17 Cell Generation and CNS Inflammation. J Neurol Neurophysiol S12:004. doi:10.4172/2155-9562.S12-004

Copyright: © 2014 Yang K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system (CNS), results from
uncontrolled auto reactive T cells that infiltrate the CNS and attack the myelin sheath. Th17 cells play a prominent role
in the pathogenesis of MS and experimental autoimmune encephalomyelitis (EAE), a mouse model of MS. Extensive
studies have focused on understanding the roles of cytokine signaling and transcriptional network in the differentiation
of Th17 cells and their pathogenicity in CNS inflammation. Aside from these events, activated T cells dynamically
reprogram their metabolic pathways to fulfill the bioenergic and biosynthetic requirements for proper T cell functions.
Emerging evidence indicates that modulation of these metabolic pathways impinges upon the differentiation of
Th17 cells and the pathogenesis of EAE. Thus, a better understanding of the functions and mechanisms of T cell
metabolism in Th17 cell biology may provide new avenues for therapeutic targeting of MS. In this review, we discuss
the recent advances in our understanding of T cell metabolic pathways involved in Th17 cell differentiation and CNS
inflammation.

Keywords

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