Metabolic Deregulation Associated with Glycemic Imbalance In Gabonese Diabetics
Guy-Stephane Padzys1, Joseph Ndanga Tiagni1, Krystina Mengue Me Ngou-Milama2, Joseph Privat Ondo3, Oriane Cordelia Aboumegone Biyogo2, Amandine Mveang Nzoghe2, Agate Gorra4, Eric Baye4 and Joel Fleury Djoba Siawaya2*
- *Corresponding Author:
- Joel Fleury Djoba Siawaya
Unités de Recherche et de Diagnostics Spécialisés
Laboratoire National de Santé Publique, B.P. 10736, Libreville, Gabon
E-mail: [email protected]
Received Date: June 05, 2017; Accepted Date: June 20, 2017; Published Date: June 24, 2017
Citation: Padzys G, Tiagni JN, Ngou-Milama KMM, Ondo JP, Biyogo OCA, et al. (2017) Metabolic Deregulation Associated with Glycemic Imbalance In Gabonese Diabetics. Diabetes Case Rep 2:125. doi: 10.4172/2572-5629.1000125
Copyright: © 2017 Padzys G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Aim: Diabetes is a metabolic disease most often associated with complications when uncontrolled. The present study aimed to investigate the relationship between diabetes-associated complications, glycemic imbalances and other metabolic deregulation in Gabonese diabetics.
Methods: 115 known diabetics were recruited from the Libreville University hospital. We collected anthropometric data and information on associated pathologies. Blood samples collected were analyzed for blood glucose, urea, creatinine, triglycerides, cholesterol fractions and transaminases.
Results: Type-2 diabetes was more prevalent in the studied population, representing 90% of cased cases. 41.7% had diabetes cases were associated with hypertension alone. 9.6% of diabetes cases had kidney failure (associated or not with hypertension and/or neuropathy). 87% patients had uncontrolled blood sugar. Creatinine and urea were significantly higher in patients with affections as compared to patients without affections (p<0.0001). In diabetics with controlled blood glucose concentration, only patients with the nephropathy had significantly high levels of creatinine and urea (p<0.05). In diabetics with uncontrolled blood glucose concentration, significantly high levels of creatinine and urea were seen in both patients with hypertension and patient with nephropathy (p<0.001).
Conclusion: The high rate of hypertension and hyperglycemia observed suggest that Gabonese diabetics are at high risk for developing nephropathies.