Metabolic Syndrome, Abnormal Glucose Tolerance and High Sensitivity-C-Reactive Protein among Women with a History of Gestational Diabetes MellitusSangeetha Shyam1, Fatimah Arshad2, Rohana Abdul Ghani3*, Norasyikin A Wahab4, Karuthan Chinna5, Nik Shanita Safii6, Yusof Barakatun Nisak7 and Nor Azmi Kamaruddin8
- *Corresponding Author:
- Rohana Abdul Ghani
MMed, Medical Discipline
Faculty of Medicine,Universiti Teknologi MARA
Kuala Lumpur, Malaysia
E-mail: [email protected]
Received date: July 22, 2014; Accepted date: August 25, 2014; Published date: September 01, 2014
Citation: Shyam S, Arshad F, Ghani RA, Wahab NA, Chinna K, et al. (2014) Metabolic Syndrome, Abnormal Glucose Tolerance and High Sensitivity- C-Reactive Protein among Women with a History of Gestational Diabetes Mellitus. J Diabetes Metab 5:424. doi: 10.4172/2155-6156.1000424
Copyright: © 2014 Shyam S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Gestational Diabetes Mellitus (GDM) is a risk factor for diabetes and cardiovascular diseases. Early detection of cardio-metabolic risks is recommended for management. This study evaluated the associations between Metabolic Syndrome (MetS), abnormal glucose tolerance and cardiovascular risk factors in Malaysian women with prior GDM.
Method: Seventy-seven, non-diabetic women post-GDM, aged 20-40 years (mean BMI: 26.4 ± 4.6kg/m2) with high type 2 diabetes risks, were evaluated at a median of four months postpartum. Their anthropometric and biochemical measurements were obtained.
Results: The overall prevalence of MetS and dysglycaemia were 22% and 29% respectively. Dysglycaemic was predominantly impaired glucose tolerance (IGT: 77%).MetS was higher among dysglycaemic subjects although also detected in 13% of normo glycaemic subjects. Eighty percent of IGT subjects did not have MetS. Sixty-eight percent of subjects had intermediate or high CVD risks (hsCRP>1mg/L). hscRP increased with obesity and was not associated with glycaemic status. Infant birth weight, maternal age and triglycerides were independent predictors of dysglycaemia (p<0.05).
Conclusion: Despite the low prevalence of MetS, elevated levels of hsCRP among these women with prior- GDM was highly prevalent. Normoglycaemic subjects with MetS demonstrated intermediate to high risk hsCRP levels. The findings also emphasize the importance of performing OGTT mainly in older post-GDM women, with higher triglycerides and infants who are large for gestational age.