alexa Metabolic syndrome and insulin signaling in kidney
ISSN: 2161-1017

Endocrinology & Metabolic Syndrome
Open Access

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Review Article

Metabolic syndrome and insulin signaling in kidney

Shoko Horita, George Seki*, Hideomi Yamada, Masashi Suzuki, Motonobu Nakamura and Toshiro Fujita

Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo Tokyo 113-0033, Japan

corresponding Author:
George Seki
Department of Internal Medicine, Faculty of Medicine
University of Tokyo,7-3-1 Hongo
Bunkyo-ku, Tokyo 113-0033, Japan
Tel: +81-3-3815-5411
Fax: +81-3-5800-8806
E-mail: [email protected]

Received Date: November 01, 2011; Accepted Date: November 30, 2011; Published Date: December 03, 2011

Citation: Horita S, Seki G, Yamada H, Suzuki M, Nakamura M, et al. (2011) Metabolic syndrome and insulin signaling in kidney. Endocrinol Metabol Syndrome S1:005. doi: 10.4172/2161-1017.S1-005

Copyright: © 2011 Horita S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Metabolic syndrome (MetS) is now recognized as a big threat for human health. It has been a problem in developed
countries for decades and also emerging similarly in developing countries. It has been also called as “Syndrome X”,
“Deadly quartet”, “Reaven’s syndrome”. Essentially these are of the same clinical status, in which insulin resistance
is the common condition. In such condition hyperinsulinemia occurs, which may have potential influence on other
organs and tissues, including kidney – glomeruli and tubules - , cardiovascular systems, liver, muscles. This review
will focus on the influence of MetS on the point of insulin resistance and its influence of kidney, especially proximal
tubules and glomeruli.

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