alexa Metabolic Syndrome Biomarkers in Type II Diabetic Ethio
ISSN: 2167-0943

Journal of Metabolic Syndrome
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Research Article

Metabolic Syndrome Biomarkers in Type II Diabetic Ethiopian Patients

Fitsum Girma Tadesse1*, Yesehak Worku2, Yeweyenhareg Feleke3 and Tarek H. El-Metwally4
1Department of Medical Microbiology, Radboud Institute for Molecular Life Sciences, Route 268, Geert Grooteplein 26-28, Nijmegen 6525 GA, Netherlands
2Department of Biochemistry, College of Medicine, Addis Ababa University, Addis Ababa, Ethiopia
3Department of Internal Medicine, Faculty of Medicine, Addis Ababa University, Addis Ababa, Ethiopia
4Faculty of Medicine, Assiut University, Assiut, POB: 71526, Egypt
Corresponding Author : Fitsum Girma Tadesse
Department of Medical Microbiology
Radboud Institute for Molecular Life Sciences, Route 268
Geert Grooteplein 26-28, Nijmegen 6525 GA, Netherlands
Tel: 251-912-627-540
Fax: 251-111-552-350
E-mail: [email protected], [email protected]
Received March 31, 2014; Accepted April 23, 2014; Published May 02, 2014
Citation: Tadesse FG, Worku Y, Feleke Y, El-Metwally TH (2014) Metabolic Syndrome Biomarkers in Type II Diabetic Ethiopian Patients. J Metabolic Synd 3:139. doi:10.4172/2167-0943.1000139
Copyright: © 2014 Tadesse FG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Background: Insulin resistance, which precedes by many years the onset of and accompanies type II diabetes (T2D), is strongly associated with a clustering of cardiovascular risk factors, termed metabolic syndrome (MetS).

Objectives: The aim of this study was to investigate the extent of MetS risk in T2D Ethiopian patients.

Methods: A total of 72 T2D patients and 20 normal healthy controls without MetS were studied. Based on the world health organization criteria, 59.72% (43/72) of the patients had MetS.

Results: Type 2 diabetic patients with MetS (0.953 ± 0.007) were significantly (P<0.01) obese than those without (0.913 ± 0.012). Plasma total triglyceride (TG) (206.9 ± 16.91) and blood pressure (138.8 ± 3.247) were strongly significantly high (P<0.001) in patients with MetS as compared to those without MetS (104.4 ± 6.766 and 122.8 ± 2.725, respectively). On the other hand, plasma high density lipoprotein-cholesterol (40.91 ± 3.070) and total peroxide (0.055 ± 0.001) were found at a significantly (P<0.05) lower amounts in patients with MetS as compared to those without (50.90 ± 2.601 and 0.052 ± 0.001, respectively). In patients with MetS, the IR index showed a significant association (P<0.05) with the dyslipidemia markers: TG (r=0.254), low density lipoprotein-cholesterol (r=0.262), and total cholesterol (r=0.320). Waist-hip circumference ratio showed a positive significant correlation with blood pressure (r=0.330, P<0.05) and C-reactive protein was strongly associated with serum insulin concentration (r=0.382, P<0.01).

Conclusion: Ethiopian T2D patients with MetS are at a greater risk of hypertensive, dyslipidemia and oxidative stress states, and developing cardiovascular disorders. Interventions should be planned to help those patients avoid/delay onset of cardiovascular complications anticipated upon the accumulation of predisposing factors that are components of MetS.

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