alexa Metabolic Syndrome in Aging Heart: Molecular Insights | OMICS International | Abstract
ISSN: 2167-0943

Journal of Metabolic Syndrome
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Review Article

Metabolic Syndrome in Aging Heart: Molecular Insights

Julieta Díaz-Juárez1, Gustavo Pastelín1 and Jorge Suarez2*

1Department of Pharmacology, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México

2Department of Medicine, University of California, San Diego, USA

*Corresponding Author:
Jorge Suarez
Department of Medicine, University of California
San Diego, USA
Tel: (858) 534-9931
Fax: (858) 534-9932
E-mail: [email protected]

Received date: July 27, 2017; Accepted date: August 04, 2017; Published date: August 12, 2017

Citation: Díaz-Juárez J, Pastelín G, Suarez J (2017) Metabolic Syndrome in Aging Heart: Molecular Insights. J Metabolic Synd 6:230. doi: 10.4172/2167-0943.1000230

Copyright: © 2017 Diaz-Juarez J, et al. This is an open-access article distributed under the terms of the creative commons attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Risk factors that define the metabolic syndrome (MetS) develop with age increasing its prevalence. Therefore, MetS can be considered an age-related health problem. Mechanism involved in aging and MetS are incompletely understood. The goal of this review is to highlight novel molecular maladaptive mechanism that tiger cardiac disease and common in aging and MetS. We focus on mitochondrial energetic function as well as mitochondrial calcium handling. In addition, we analyzed the role of O-GlcNAcylation which is a posttranslational modification that triggers multiple signaling pathways.

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