alexa Metabolomics Study of Protective Effects of Shexiang Baoxin Pill and its Bioactive Constitutes Combination in Treating the Early Period of Acute Myocardial Infarction in Rats
ISSN: 2327-5162

Alternative & Integrative Medicine
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Research Article

Metabolomics Study of Protective Effects of Shexiang Baoxin Pill and its Bioactive Constitutes Combination in Treating the Early Period of Acute Myocardial Infarction in Rats

Xiang L1, Han L1, Jiang P1, Wang S1, Hu Y1, Zhang W1-3* and Liu R1*

1School of Pharmacy, Second Military Medical University, Shanghai 200433, P.R. China

2School of Pharmacy, Shanghai JiaoTong University, Shanghai 200030, P.R. China

3King Saud University, Riyadh11451, Saudi Arabia

*Corresponding Authors:
Weidong Zhang
School of Pharmacy
Second Military Medical University
No. 325 Guohe Road, Shanghai, 200433, P.R. China
Fax: +86-21-81871244
E-mail: [email protected]

Runhui Liu
School of Pharmacy
Second Military Medical University
No. 325 Guohe Road, Shanghai, 200433, P.R. China
Fax: +86-21-81871245
E-mail: [email protected]

Received date May 21, 2013; Accepted date July 03, 2013; Published date July 05, 2013

Citation: Xiang L, Han L, Jiang P, Wang S, Hu Y, et al. (2013) Metabolomics Study of Protective Effects of Shexiang Baoxin Pill and its Bioactive Constitutes Combination in Treating the Early Period of Acute Myocardial Infarction in Rats. Altern Integr Med 2:127. doi:10.4172/2327-5162.1000127

Copyright: © 2013 Xiang L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Ginsenoside Re, ginsenoside Rb1, muscone, cinnamic acid, bufalin, cholic acid and borneol are the main active ingredients of Shexiang Baoxin Pill (SBP) for protective effects on acute myocardial infarction (AMI). In this study, the protective effects of SBP, single component treatments and combination treatment of 7 bioactive ingredients of SBP (SFSBP) were investigated by metabolomics technology. Liquid chromatography/quadrupole time-of-flight mass spectrometry (LC-Q-TOF/MS) has been used to analyze the plasma samples of AMI rats. Partial least squares discriminate analysis (PLS-DA) models were built to evaluate the protective effects of different treatments at whole level. Reverse effect on mean levels of 19 identified biomarkers were also carried out to investigate the protective effects of different treatments. The results showed that the protective effect of multi-component medicines (SBP and SFSBP) was superior to 7 single-component treatments, demonstrated the multi-effective advantages of multicomponent treatments (SBP and SFSBP). Meanwhile, the reverse effects of SFSBP were inferior to SBP, indicating that there might be other bioactive components in SBP taking responsibility for the protection effect on AMI rats, and the simplified formula of SBP should be further optimized, while also revealed the rationality of TCM formula, and it cannot be simply substituted by a combination of bioactive ingredients.

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