alexa Metabolomics: Which Role in Asphyxia and Sepsis?
ISSN: 2155-6148

Journal of Anesthesia & Clinical Research
Open Access

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Review Article

Metabolomics: Which Role in Asphyxia and Sepsis?

Gabriele Finco1, Paola Scano2, Ernesto d’Aloja3, Emanuela Locci3, Mario Musu1, Paolo Mura1, Vassilios Fanos4 and Antonio Noto4*
1Department of Anesthesiology, Cagliari University, Italy
2Department of Chemical and Geological Sciences, Cagliari University, Italy
3Department of Public Health, Clinical and Molecular Medicine-Forensic Science Unit-Cagliari University, Italy
4Department of Pediatrics and Clinical Medicine, Section of Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, Cagliari University, Italy
Corresponding Author : Antonio Noto
Department of Pediatrics and Clinical Medicine
Section of Neonatal Intensive Care Unit
Puericulture Institute and Neonatal Section
Cagliari University, Italy
Tel: 0039/3331014029
E-mail: [email protected]
Received April 25, 2014; Accepted July 21, 2014; Published July 28, 2014
Citation: Finco G, Scano P, d’Aloja E, Locci E, Musu M, et al. (2014) Metabolomics: Which Role in Asphyxia and Sepsis?. J Anesth Clin Res 5:420 doi: 10.4172/2155-6148.1000420
Copyright: © 2014 Finco G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Metabolomics is a new “omics” approach concerning the high-throughput identification, quantification and characterization of endogenous and exogenous metabolites. This new technique is gaining consideration upon medical practice improving the single metabolite analysis as well as measuring the response to treatment in intensive care units. However, despite great efforts, very little research has new biomarkers or specific metabolic profiles, which characterize disorders such as asphyxia and sepsis. Here, we point out some of the recent works published in literature regarding the management of these conditions having high mortality and morbidity rates. The purpose of this review is also to highlight the ability of metabolomics to find early biomarkers for these conditions as well as to predict the development of side\effects due to the therapy. The goal is to demonstrate that the metabolomics technique can be considered a viable option for the study of these conditions, which may help to develop a better care in intensive departments.

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