Metal-Induced Oxidative Stress in Egyptian Women with Breast Cancer
- *Corresponding Author:
- Rania H Abdel Rahman
Forensic Medicine and Clinical Toxicology Department
Mansoura University, 101 Gomhouria St.
E-mail: [email protected]
Received date: August 03, 2012; Accepted date: September 10, 2012; Published date: September 13, 2012
Citation: Shams N, Said SB, Salem TAR, Abdel-Rahman RH, Roshdy S, et al. (2012) Metal-Induced Oxidative Stress in Egyptian Women with Breast Cancer. J Clinic Toxicol 2:141. doi: 10.4172/2161-0495.1000141
Copyright: © 2012 Shams et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Some trace metals are toxic and claimed to be carcinogenic. The present work aimed to determine the levels of some trace metals in breast tissues (healthy and tumor specimens) and to evaluate their concentrations in relation to the oxidative stress status in breast cancer which is a major health problem among Egyptian women. This study included 127 female patients with breast swelling. Analysis of trace metals in breast tissue was done using Atomic Absorption Spectrophotometry (AAS). Lipid peroxidation and oxidative status were assessed. There were statistically high levels of iron, zinc and copper in the benign and malignant breast tissues in comparison to the control group. Higher Malondialdehyde (MDA) levels were detected in patients with breast tumors while Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GSH), Glutathione-S-transferase (GST) and Nitric oxide (NO) were low in comparison to the healthy group. In conclusion, the alteration of the elemental content in cancerous breast tissues and the disruption of oxidant/antioxidant balance highlight the role of trace metals in cancer development.