Metformin and Not Diabetes Influences the Survival of Resected Early Stage NSCLC Patients
- *Corresponding Author:
- Sai Yendamuri, MD, FACS, FCCP
Department of Thoracic Surgery Roswell Park Cancer Institute
Elm and Carlton Streets, Buffalo, NY 1426, USA
Tel: (716) 845 5873
Fax: (716) 845 7692
E-mail: [email protected]
Received Date: April 26, 2014; Accepted Date: June 27, 2014; Published Date: June 30, 2014
Citation: Dhillon SS, Groman A, Meagher A, Demmy T, Warren GW, et al. (2014) Metformin and Not Diabetes Influences the Survival of Resected Early Stage NSCLC Patients. J Cancer Sci Ther 6:217-222. doi: 10.4172/1948-5956.1000275
Copyright: © 2014 Dhillon SS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Published data suggest that diabetes influences survival of patients with lung cancer. The anti-cancer effect of metformin confounds this association. We sought to study the association of diabetes and metformin with survival in patients undergoing resection of stage I non-small cell lung cancer (NSCLC).
Methods: Pathologic stage I NSCLC patients undergoing anatomic resection from 2002 to 2011 were studied. A diagnosis of diabetes and diabetic medication use were identified through records. Univariate and multivariate analyses examined the association of diabetes and metformin usage with overall survival (OS).
Results: 409 eligible patients were included in the analysis - excluding patients with neoadjuvant therapy, more than one lung cancer, or resection less than lobectomy. 71 (17.4%) patients were diabetics and 41 (10.0%) used metformin. With a median follow up of 44 months, univariate analysis demonstrates that diabetes had no effect on OS (P=0.75); however, metformin use was associated with improved OS (median survival not reached vs. 60 months; P=0.02). Metformin use remained an important predictor of good survival in multivariate analysis (HR=3.08; P<0.01) after adjusting for age, gender, pathologic stage, histology and smoking status.
Conclusion: Metformin use rather than diabetes is associated with improved long-term survival in Stage I NSCLC patients.