alexa Metformin Loaded Carbopol Gel for lowering the Intra-Ab
ISSN: 0975-0851

Journal of Bioequivalence & Bioavailability
Open Access

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Research Article

Metformin Loaded Carbopol Gel for lowering the Intra-Abdominal Visceral Fat

Ahmed AH Abdellatif1* and Hesham M Tawfeek2

1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar, Assuit, Egypt

2Department of Indsutrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt

*Corresponding Author:
Ahmed AH Abdellatif, PhD
Department of Pharmaceutics and Industrial pharmacy
Faculty of Pharmacy, Al Azhar University
Assuit 71524, Egypt
Tel: +201016660069
E-mail: [email protected]

Received Date: February 12, 2016 Accepted Date: April 21, 2016 Published Date: April 28, 2016

Citation: Abdellatif AAH, Tawfeek HM (2016) Metformin Loaded Carbopol Gel for lowering the Intra-Abdominal Visceral Fat. J Bioequiv Availab 8:149-152. doi:10.4172/jbb.1000286

Copyright: © 2016 Abdellatif AAH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The aim of this study was to prove the principle of local delivery of metformin hydrochloride, METHCl, to the abdomen area in order to reduce the intra-badominal visceral fat compared to the METHCL oral tablets. Intraabdominal visceral and subcutaneous fat were highly correlated with body weight of obese people. So, this will be beneficial to assist wight loss in those individuals. Furthermore, oral METHCl tablets (600 mg) might show reduction in weight in diabetic pateints. However, the reqiured high doses is still an issue which put the patients under stress of METHCl side effects. In this preliminary trial, METHCl was formulated in the form of local hydrogel using the carbopol 934 within very small drug dose (6 mg/g). The prepared hydrogel was pharmaceutically evaluated for its pH, viscosity, spreadability, and in vitro release. Furthermore, the abdominal fat lowering activity of METHCl gel was compared to the oral METHCl tablets and control (placebo) groups in human volunteers. The study showed that the prepared METHCl gel significantly (p<0.05, ANOVA/Tukey) decrease the diameter of the abdomen compared to the placebo group and to 50% of participant taking oral METHCl tablets after three weeks treatment. In addition, the group taking METHCl oral tablets failed to decrease the inta-abdominal fat in approximately 50% of participants. In conclusion, METHCl hydrogel could be considered a promising novel formulation which can decrease the accumulated fats in the abdomen reigon with small dose comapred to oral METHCl tablets.

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