Metformin Use in Adolescents: Old and New Therapeutic PerspectivesFawziya Alkhalaf1,2, Ashraf T Soliman2,3*, and Vincenzo De Sanctis4
- *Corresponding Author:
- Ashraf Soliman
Professor of Pediatrics and Endocrinology
Department of Pediatric Hamad Medical Center
(HMC), Doha - Qatar. (*) HMC, Qatar
E-mail: [email protected]
Received date: October 02, 2014; Accepted date: November 17, 2014; Published date: November 19, 2014
Citation: Alkhalaf F, Soliman AT, De Sanctis V (2014) Metformin Use in Adolescents: Old and New Therapeutic Perspectives. J Diabetes Metab 5:472. doi:10.4172/2155-6156.1000472
Copyright: © 2014 Alkhalaf F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Metformin (dimethylbiguanide) is now considered to be the most widely prescribed agent in the treatment of diabetes. The global increase in the prevalence of obesity among children and adolescents is accompanied by the appearance and increasing prevalence of insulin resistance, prediabetes and type 2 diabetes mellitus (T2DM). In addition, children and adolescents with premature pubarche and polycystic ovary have considerable degree of insulin resistance. The insulin sensitizing action/s of Metformin encourage (add s to encourage to be encourages) many investigators and physician to use it as the primary drug of choice in these conditions for both prevention and treatment. However, long term controlled studies are still required to assess the degree and duration of effectiveness and safety of using Metformin .In this review the old and new therapeutic perspectives of this drug are presented.