Methotrexate Therapy in Deep Venous Thrombosis in Behcet Disease in Children
|Lucia Burac1*, Genel Sur1, Ioan Marian2, Tudor Vasile3, Sorin Dudea4 and Camelia Bud1|
|12nd Pediatric Clinic, Cluj-Napoca, Romania|
|21st Medical Clinic, Cluj-Napoca, Romania|
|33rd Medical Clinic, Cluj-Napoca, Romania|
|4Radiology Department, University of Medicine and Pharmacy, Cluj-Napoca, Romania|
|*Corresponding Author :||Dr. Lucia Burac, MD
Pediatric Clinic no. 2
Crisan street no. 5, 400177 Cluj Napoca, Romania
E-mail: [email protected]
|Received March 11, 2014; Accepted April 25, 2014; Published May 02, 2014|
|Citation: Burac L, Sur G, Marian I, Vasile T, Dudea S, etal. (2014) Methotrexate Therapy in Deep Venous Thrombosis in Behcet Disease in Children. Intern Med 4:153. doi:10.4172/2165-8048.1000153|
|Copyright: © 2014 Burac L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
Behcet disease is a chronic condition, systemic disease, with etiopathology still incomplete known but in witch are involved immune and genetic factors who may lead to inflammation and coagulation conditions. Authors present the case of a patient, masculine sex, 14 years old, diagnosed with Behcet disease, who had the vascular manifestation, with deep and superficial lower extremity vein thrombosis, that appeared at more than five years after first signs of disease (recurrent oral ulcerations). The patient had not presented positive markers for primary thrombophilia. Methotrexate therapy led to complete disappearance of lower extremity vein thrombosis, after about one year of treatment (as shown in Doppler vascular ultrasound). No side effect was observed related to Methotrexate therapy.
Conclusions: Methotrexate therapy may be a very efficient alternative treatment in deep lower extremity vein thrombosis in Behcet disease, without anticoagulants association.