alexa Methylenetetrahydrofolate Reductase Gene Polymorphisms and Cardiovascular Diseases | OMICS International | Abstract
ISSN: 2168-9296

Cell & Developmental Biology
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Review Article

Methylenetetrahydrofolate Reductase Gene Polymorphisms and Cardiovascular Diseases

Mohammad Afaque Alam*, Ph.D

Department of Pediatrics, College of Medicine, Drexel University, Philadelphia, PA, USA.

*Corresponding Author:
Mohammad Afaque Alam
Department of Pediatrics
College of Medicine
Drexel University, 894 Union Ave
Memphis,, TN 38103, USA
Tel: +1-901-518-6443
E-mail: [email protected]

Received Date: May 09, 2016; Accepted Date: May 13, 2016 ; Published Date: May 21, 2016

Citation: Alam MA (2016) Methylenetetrahydrofolate Reductase Gene Polymorphisms and Cardiovascular Diseases. Cell Dev Biol 5:172. doi:10.4172/2168-9296.1000172

Copyright: © 2016 Alam MA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

A growing body of evidence suggests that mutations in MTHFR gene are involved in cardiovascular diseases (CVD) - cardiac development, atherosclerosis, myocardial infarction, heart failure, hypertension, aneurysms- and several other disease- cancers, neurological and metabolic disorders. Genetic variations in other genes are added risk for CVD- a leading cause of morbidity and mortality around the globe. Accumulating data over the decade has enhanced our understanding of MTHFR deficiency and diseases associated risk. The frequency of MTHFR 677 C→T and 1298 A→C gene mutations varies substantially in different regions of the world among different racial and ethnic groups. In particular, 677C→T and 1298 A→C variant are associated with clinical manifestation of almost all noncommunicable diseases. This review describes the roles of MTHFR gene mutation in CVD and prospective therapies for heart disease treatment.

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