alexa Metronidazole and Tacrolimus Interaction in a Kidney Transplant Recipient | OMICS International
ISSN: 2165-7920

Journal of Clinical Case Reports
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Case Report

Metronidazole and Tacrolimus Interaction in a Kidney Transplant Recipient

Yusuf Ziya Şener* and Tolga Yildirim

Hacettepe Universitesi, Turkey

*Corresponding Author:
Yusuf Ziya Şener
Hacettepe Universitesi, Turkey
Tel: +903051001
E-mail: [email protected]

Received Date: January 02, 2017; Accepted Date: April 22, 2017; Published Date: April 27, 2017

Citation: Şener YZ, Yildirim T (2017) Metronidazole and Tacrolimus Interaction in a Kidney Transplant Recipient. J Clin Case Rep 7:953. doi: 10.4172/2165- 7920.1000953

Copyright: © 2017 Şener YZ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

We present a 56-year-old male kidney transplant recipient who was hospitalized for acute kidney injury due to gastroenteritis related volume depletion and had kindey function deterioration secondary to rising plasma levels of tacrolimus after metronidazole administration. Tacrolimus dose was decreased and arranged daily by closely drug level monitoring. His creatinine value returned to his basal levels after metronidazole was stopped and his tacrolimus levels were kept in target range. Tacrolimus is metabolized primarily in the liver by CYP3A enzymes and drugs that affect CYP3A functions such as metronidazole can cause elevated tacrolimus plasma levels that results in nephrotoxicity. This case teach us that calcineurin inhibitors should be closely monitored in kidney transplant recipients during metronidazole treatment.

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