MHC Class 1-Related Chain A and B Ligands are Differently Expressed in Cancer Cell Lines
Oremo JAA*, Zhang Xiao and Zhu Sha
Department of Microbiology and Immunology, Basic Medical Sciences, Zhengzhou University, Zhengzhou Henan, 450001, China
- *Corresponding Author:
- Judith Annah Apondi Oremo
Department of Microbiology and Immunology
Basic Medical Sciences, Zhengzhou University
Zhengzhou Henan, 450001, China
Tel: 36,000 (2010)
E-mail: [email protected]
Received date: January 14, 2016 Accepted date: January 30, 2016 Published date: February 03, 2016
Citation: Oremo JAA, Xiao Z, Sha Z (2016) MHC Class 1-Related Chain A and B Ligands are Differently Expressed in Cancer Cell Lines. Immunol Disord Immunother 1:103.
Copyright: © 2016 Oremo JAA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The MHC class I related chain A and B have been of much interest in the recent past MHC class 1 related gene A/B (MICA/B) are ligands of the NKG2D, which is an activating receptor expressed on T and NK cells (NK cells are effector cells of the innate immune system and their functions are regulated by a number of killer cell-inhibitory and -activating receptors.).Their expression on normal tissues is highly restricted but in the event of tissue transformation and infected cells, MICA/B expression is up-regulated leading to NK killing activity. MICA/B are shedded in the serum of cancer patients (sMICA/B) whereby sustained expression of this MIC affects the killing activity of NK cells and T cells. In this summary review we look at how differently MIC A/B is expressed in Cancer cell.