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Microangiopathic Hemolytic Anemia (MAHA), High Alkaline Phosphatase and D-dimer Levels and Bone Marrow Infiltration as the First Presentation of Metastatic Signet Ring Cell Carcinoma of Gastric Origin: A Rare Case Report | Abstract
ISSN: 2577-0535

Journal of Cancer Clinical Trials
Open Access

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Case Report

Microangiopathic Hemolytic Anemia (MAHA), High Alkaline Phosphatase and D-dimer Levels and Bone Marrow Infiltration as the First Presentation of Metastatic Signet Ring Cell Carcinoma of Gastric Origin: A Rare Case Report

Sebnem Izmir Guner1*, Teoman Yanmaz2, Didem Karacetin3, Muhammed Fatih Aydin4, Ali Onder Atca5 and Oner Dogan6

1Department of Hematology, Istanbul Kemerburgaz University, Medical Faculty, Istanbul, Turkey

2Department of Medical Oncology, Istanbul Kemerburgaz University, Medical Faculty, Istanbul, Turkey

3Istanbul Research and Training Hospital Department of Radiation Oncology, Istanbul-Turkey

4Department of Gastroenterology, Istanbul Kemerburgaz University, Medical Faculty, Istanbul, Turkey

5Department of Radyology, Istanbul Kemerburgaz University, Medical Faculty, Istanbul, Turkey

6Department of Pathology, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey

*Corresponding Author:
Sebnem Izmer Guner
Istanbul Kemerburgaz University Medical Park Bahcelievler Hospital Hematology and Adult Bone Marrow Transplantation Division
Istanbul-Turkey
Tel: 0090532 6148498
E-mail: [email protected]

Received Date: September 21, 2015 Accepted Date: September 23, 2015 Published Date: September 28, 2015

Citation: Guner SI, Yanmaz T, Karacetin D, Aydin MF, Atca AO, et al. (2015) Microangiopathic Hemolytic Anemia (MAHA), High Alkaline Phosphatase and D-dimer Levels and Bone Marrow Infiltration as the First Presentation of Metastatic Signet Ring Cell Carcinoma of Gastric Origin: A Rare Case Report. J Cancer Clin Trials 1:101. doi: 10.4172/jcct.1000101

Copyright: © 2015 Guner SI, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Microangiopathic haemolytic anaemia (MAHA) occurs seldom as a paraneoplastic syndrome in some solid tumors, but MAHA companionship by signet ring cell carcinoma (SRCC) of gastric origin is very rare. This case report describes a 46-year-old man who initially presented with unendurable back and abdomen pain, he has also jaundice, anaemia, thrombositopenia, elevated bilirubin-D-dimer and alkaline phoshatase levels. He was diagnosed with MAHA on the basis of the laboratory findings that revealed anaemia with schistocytes, and a negative direct Coombs’ test. Bone marrow and peripheral blood smear examinaton of the patients revealed out the diagnosis which was performed because of the progression of anaemia and thrombositopenia. However, the primary origin of this signet ring cell carcinoma (SRCC) was found in the stomach.

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