alexa Microbial and Immune Biomarkers in Infants at Risk for Allergies Fed an Intact Cows Milk Formula Containing Specific Non-Digestible Carbohydrates
ISSN: 2161-0509

Journal of Nutritional Disorders & Therapy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Microbial and Immune Biomarkers in Infants at Risk for Allergies Fed an Intact Cows Milk Formula Containing Specific Non-Digestible Carbohydrates

Karen Knipping1,2*, Anna Orsi3, Günther Boehm1,4, Francesca Castoldi5, Johan Garssen1,2, Maria Giannì3, Tom Groot Kormelink2, Gianluca Lista5, Paola Marangione5, Frank Redegeld2, Paola Roggero3 and Fabio Mosca3

1Danone Research-Centre for Specialised Nutrition, Wageningen, The Netherlands

2Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands

3Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Department of Maternal and Pediatric Sciences, University of Milan, Italy

4Sophia Children’s Hospital, Erasmus University, Rotterdam, The Netherlands

5NICU, “V.Buzzi” Children’s Hospital, ICP, Milan, Italy

*Corresponding Author:
Karen Knipping
Danone Research Centre for Specialised Nutrition
P.O. Box 7005, 6700 CA Wageningen, The Netherlands
E-mail: [email protected]

Received Date: July 18, 2012; Accepted Date: August 23, 2012; Published Date: August 25, 2012

Citation: Knipping K, Orsi A, Boehm G, Castoldi F, Garssen J, et al. (2012) Microbial and Immune Biomarkers in Infants at Risk for Allergies Fed an Intact Cow’s Milk Formula Containing Specific Non-Digestible Carbohydrates. J Nutr Disorders Ther 2:119. doi: 10.4172/2161-0509.1000119

Copyright: © 2012 Knipping K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Background: Oligosaccharides may support postnatal immune development by influencing the constitution of gastrointestinal microbiota. This prospective, double-blind, randomised, placebo controlled trial investigated the effect of a specific prebiotic mixture of short chain galactooligosaccharides (scGOS) and long chain fructooligosaccharides (lcFOS) on microbiota and immune biomarkers during the first six months of life in high risk infants for allergies fed a formula based on intact cow’s milk protein.

Methods: If formula feeding was started, the infant was randomly assigned to one of two cow’s milk formula groups (0.8 g/100 ml scGOS/lcFOS or maltodextrine as control). The faecal microbiota of the scGOS/lcFOS and control groups was analysed. In a subgroup blood was collected at the age of six months for serum biomarkers. A reference group consisted of 90 exclusively breast fed infants up to six months of age.

Results: In both the prebiotic group and control group a total of 51 infants completed the study. The scGOS/lcFOS supplementation was associated with a significantly higher number of faecal bifidobacteria and lactobacilli counts compared to controls, accompanied by significantly lower pH values in the faeces. In the serum, the scGOS/lcFOS group showed a trend towards a decrease in total IgE levels as well as a trend towards a decrease in the percentage of children with elevated (>15 kU/l) IgE. There were no differences found in kappa Ig-fLC and lambda Ig-fLC between the two groups.

Conclusions: scGOS/lcFOS administration significantly influences the composition of bifidobacteria and lactobacilli. There were some observations with respect to the immune parameters which need further investigation.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]online.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords