alexa Microbial and Immune Biomarkers in Infants at Risk for Allergies Fed an Intact Cows Milk Formula Containing Specific Non-Digestible Carbohydrates | OMICS International | Abstract
ISSN: 2161-0509

Journal of Nutritional Disorders & Therapy
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Research Article

Microbial and Immune Biomarkers in Infants at Risk for Allergies Fed an Intact Cows Milk Formula Containing Specific Non-Digestible Carbohydrates

Karen Knipping1,2*, Anna Orsi3, Günther Boehm1,4, Francesca Castoldi5, Johan Garssen1,2, Maria Giannì3, Tom Groot Kormelink2, Gianluca Lista5, Paola Marangione5, Frank Redegeld2, Paola Roggero3 and Fabio Mosca3

1Danone Research-Centre for Specialised Nutrition, Wageningen, The Netherlands

2Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands

3Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Department of Maternal and Pediatric Sciences, University of Milan, Italy

4Sophia Children’s Hospital, Erasmus University, Rotterdam, The Netherlands

5NICU, “V.Buzzi” Children’s Hospital, ICP, Milan, Italy

*Corresponding Author:
Karen Knipping
Danone Research Centre for Specialised Nutrition
P.O. Box 7005, 6700 CA Wageningen, The Netherlands
E-mail: [email protected]

Received Date: July 18, 2012; Accepted Date: August 23, 2012; Published Date: August 25, 2012

Citation: Knipping K, Orsi A, Boehm G, Castoldi F, Garssen J, et al. (2012) Microbial and Immune Biomarkers in Infants at Risk for Allergies Fed an Intact Cow’s Milk Formula Containing Specific Non-Digestible Carbohydrates. J Nutr Disorders Ther 2:119. doi: 10.4172/2161-0509.1000119

Copyright: © 2012 Knipping K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: Oligosaccharides may support postnatal immune development by influencing the constitution of gastrointestinal microbiota. This prospective, double-blind, randomised, placebo controlled trial investigated the effect of a specific prebiotic mixture of short chain galactooligosaccharides (scGOS) and long chain fructooligosaccharides (lcFOS) on microbiota and immune biomarkers during the first six months of life in high risk infants for allergies fed a formula based on intact cow’s milk protein.

Methods: If formula feeding was started, the infant was randomly assigned to one of two cow’s milk formula groups (0.8 g/100 ml scGOS/lcFOS or maltodextrine as control). The faecal microbiota of the scGOS/lcFOS and control groups was analysed. In a subgroup blood was collected at the age of six months for serum biomarkers. A reference group consisted of 90 exclusively breast fed infants up to six months of age.

Results: In both the prebiotic group and control group a total of 51 infants completed the study. The scGOS/lcFOS supplementation was associated with a significantly higher number of faecal bifidobacteria and lactobacilli counts compared to controls, accompanied by significantly lower pH values in the faeces. In the serum, the scGOS/lcFOS group showed a trend towards a decrease in total IgE levels as well as a trend towards a decrease in the percentage of children with elevated (>15 kU/l) IgE. There were no differences found in kappa Ig-fLC and lambda Ig-fLC between the two groups.

Conclusions: scGOS/lcFOS administration significantly influences the composition of bifidobacteria and lactobacilli. There were some observations with respect to the immune parameters which need further investigation.


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