alexa Microbial Transformations of Plant Origin Compounds as a Step in Preparation of Highly Valuable Pharmaceuticals
ISSN: 2157-7609

Journal of Drug Metabolism & Toxicology
Open Access

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Review Article

Microbial Transformations of Plant Origin Compounds as a Step in Preparation of Highly Valuable Pharmaceuticals

Blaga Mutafova1*, Sava Mutafov1, Pedro Fernandes2 and Strahil Berkov3

1The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria

2Universidade Lusofona de Humanidades e Tecnologias, Lisboa, Portugal

3Institute of Biodiversity and Ecosystem Research, Bulgarian Academy of Sciences, Sofia, Bulgaria

*Corresponding Author:
Blaga Mutafova
The Stephan Angeloff Institute of Microbiology
Bulgarian Academy of Sciences, Sofia, Bulgaria
Tel: +359 2 979 3154
Fax: +359 2 870 01 09
E-mail: [email protected]; [email protected]

Received date: April 11, 2016; Accepted date: Apr 25, 2016; Published date: May 10, 2016

Citation: Mutafova B, Mutafov S, Fernandes P, Berkov S (2016) Microbial Transformations of Plant Origin Compounds as a Step in Preparation of Highly Valuable Pharmaceuticals. J Drug Metab Toxicol 7:204. doi:10.4172/2157-7609.1000204

Copyright: © 2016 Mutafova B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The aim of the paper is to present microbial transformation reactions as a step in the preparation of drugs or their key intermediates from plant derived compounds. Described are some successful applications of microbial transformation processes for preparation of steroid drugs and/or their important intermediates as well as some microbial transformations of terpenes, alkaloids, flavonoids and poly(phenols) affording derivatives with improved biological activities.


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