alexa Microencapsulation of Ibuprofen into Polyvinylpyrrolidone Using Supercritical Fluid Technology | OMICS International
ISSN: 2157-7048

Journal of Chemical Engineering & Process Technology
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Research Article

Microencapsulation of Ibuprofen into Polyvinylpyrrolidone Using Supercritical Fluid Technology

Safaa M Yousif1, Ali H Al-Marzouqi2, and Mahmoud A Mohsin3*

1Department of Applied Mathimatics and Sciences, Khalifa University of Science, Technology and Research, Abu Dhabi, United Arab Emirates

2Department of Chemical and Petroleum Engineering, United Arab Emirates University, PO Box 15551, Al-Ain, United Arab Emirates

3Department of Chemistry, University of Sharjah, PO Box 27272, Sharjah, United Arab Emirates

*Corresponding Author:
Mahmoud A Mohsin
Department of Chemistry
University of Sharjah, PO Box 27272
Sharjah, United Arab Emirates
Tel: 97165585000;
E-mail: [email protected]

Received date: July 28, 2016; Accepted date: August 05, 2016; Published date: August 13, 2016

Citation: Yousif SM, Al-Marzouqi AH, Mohsin MA (2016) Microencapsulation of Ibuprofen into Polyvinylpyrrolidone Using Supercritical Fluid Technology. J Chem Eng Process Technol 7:306. doi: 10.4172/2157-7048.1000306

Copyright: © 2016 Yousif SM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Osteoarthritis is a disease that attacks human bones especially in older people and usually non-steroidal antiinflammatory drugs are being prescribed for patients with Osteoarthritis. These kinds of drugs usually have low aqueous solubility, dissolution and bioavailability. In order to maximize their therapeutic effects, these properties should be develped and enhanced. The purpose of this study was to reduce the particle size of ibuprofen by forming microparticles and thus enhance its dissolution rate. Ibuprofen was encapsulated into a polymer (polyvinylpyrrolidone) using supercritical fluid technology (supercritical CO2) to form drug-polymer microparticles. Dissolution rate and surface characteristics of the prepared drug-polymer microparticles were measured using various characterization techniques such as fourier transform infrared spectroscopy (FTIR), ultraviolet spectroscopy (UV), transmission electron microscopy (TEM), scanning electron microscope (SEM), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). Various drug-polymer formulations were prepared depending on the operating conditions (i.e., different temperatures, pressures, flow rates and different drug solution:CO2 volume ratio). Results from TEM images and FTIR graphs showed that microparticles were successfully prepared. Different conditions gave different morphologies of drug-polymer microparticles as was confirmed using SEM analysis. Finally, dissolution rate of the drug-polymer microparticles in a simulated gastric fluid showed a promising result and better drug release controll over extended period of two hours in comparesion with uncapsulated Ibuprofen.

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