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ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
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Review Article

MicroRNA and Cardiac Stem Cell Therapy

Claudia Serradifalco, Giovanni Zummo and Valentina Di Felice*

Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche, via del vespro 129, 90127 Palermo, Italy

*Corresponding Author:
Valentina Di Felice, BSc, PhD
Dipartimento BioNeC
Via del vespro 129, 90127 Palermo, Italy
Tel: 0039-091-6553575
Fax: 0039-091-6553580
E-mail: [email protected]

Received date: April 25, 2012; Accepted date: June 14, 2012; Published date: June 16, 2012

Citation: Serradifalco C, Zummo G, Felice VD (2012) MicroRNA and Cardiac Stem Cell Therapy. J Clin Exp Cardiolog S11:001. doi: 10.4172/2155-9880.S11-001

Copyright: © 2012 Serradifalco C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Cardiac Progenitor Cells (CPCs) are multipotent cells of the myocardium. They are located inside niches of the heart muscle, can be isolated, characterized and used for cardiac regeneration in stem cell therapy. Actually, CPCs may be isolated by tissue digestion with or without cell sorting, but it is difficult to achieve the maximum level of differentiation when these cells are implanted into a damaged myocardium.

The knowledge recently acquired on small molecules of non-coding RNAs, microRNA (miRNA), may improve the use of these cells in stem cell therapy. In fact, these small molecules may be attached to devices or adminstered as they are or in combination with nanoparticles in order to drive the correct differentiation of stem cells. Regarding heart regeneration, we can acquire knowledge from the role of miRNAs in heart development and use it to reprogram CPCs to gain the correct three-dimensional structure of the cardiac muscle.

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