MicroRNA Biomarkers for Early Detection of Embryonic Malformations in PregnancyXuezheng Li1 and Zhiyong Zhao2*
- *Corresponding Author:
- Zhiyong Zhao
Department of Obstetrics, Gynecology and Reproductive Sciences
University of Maryland School of Medicine, Baltimore
MD 21201, USA
Tel: (410) 706-8401
E-mail: [email protected]
Received date: July 31, 2014; Accepted date: October 07, 2014; Published date: October 14, 2014
Citation: Li X and Zhao Z (2014) MicroRNA Biomarkers for Early Detection of Embryonic Malformations in Pregnancy. J Biomol Res Ther 3:119. doi: 10.4172/2167-7956.1000119
Copyright: 2014 Li X, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Congenital birth defects, manifested in newborn infants, are formed during early embryogenesis. Targeted and individualized interventions to prevent birth defects require early detection of risk and signs of developmental abnormalities. Current diagnosis of structural anomalies largely relies on ultrasonography, which can only detect abnormities after their formation in fetuses. Biomolecules, mainly proteins, in maternal blood have been used as indicators of fetal anomalies; however, they lack adequate sensitivity for detecting embryonic malformations. Recently, cell-free microRNAs (miRNAs) have been found in blood and evaluated as biomarkers for diseases. Expression of certain miRNAs in maternal plasma has been shown to be correlated with birth defects in infants. Although their reliability and sensitivity remain to be validated, miRNAs, which can be amplified and sequenced, are potentially sensitive and specific biomarkers for early embryonic dysmorphogenesis.