MicroRNAÃ¢ÂÂMediated Regulation of Apoptosis in Osteosarcoma
Endocrine Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts, 02114, USA
- *Corresponding Author:
- Masako Shimada
Thier 10, 50 Blossom Street
Boston, MA 02114, USA
E-mail: [email protected]du
Received date: March 08, 2013; Accepted date: March 21, 2013; Published date: April 01, 2013
Citation: Shimada M (2013) MicroRNA–Mediated Regulation of Apoptosis in Osteosarcoma. J Carcinogene Mutagene S6:001. doi: 10.4172/2157-2518.S6-001
Copyright: © 2013 Shimada M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Osteosarcoma is the most common primary bone cancer that predominantly affects children and young adolescents. Despite the progress in understanding the pathophysiology of osteosarcoma, it remains gravely influencing mobility and mortality of those young patients. A balance between cell proliferation and apoptosis is often dysregulated in cancer; tumor cells often show accelerated proliferation and reduced apoptosis, resulting in uncontrolled cancer cell growth. The recent discovery of microRNAs has added an exciting new layer of research interest in the fields of medical research in general including cancer. miRNAs are a class of 22~25 nucleotide non-coding RNAs that play a critical role in epigenetic modification of physiological functions of their target genes. Various pathway-specific and tumor-specific miRNAs have been identified and the mechanisms, by which they regulate pathological characteristics of cancer cells, have been elucidated intensively during the past several years. In this review, we summarize current knowledge of apoptosis-related miRNAs in osteosarcoma and their future therapeutic potentials.