MicroRNA Regulated Macrophage Activation in ObesitySrikanth Kamanemi1, Wei Ying2, Fuller W Bazer2 and Beiyan Zhou1*
- *Corresponding Author:
- Dr. Beiyan Zhou
Department of Physiology and Pharmacology
CVM, Texas A&M University
College Station, TX 77843-4466, USA
E-mail: [email protected]
Received date: May 30, 2013; Accepted date: July 03, 2013; Published date: July 05, 2013
Citation: Kamanemi S, Ying W, Bazer FW, Zhou B (2013) MicroRNA Regulated Macrophage Activation in Obesity. J Nutr Food Sci 3:217. doi:10.4172/2155-9600.1000217
Copyright: © 2013 Kamanemi S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Obesity and many other metabolic disorders, including type 2 diabetes and atherosclerosis, have conventionally been viewed as lipid storage disorders caused by over nutrition. Research has demonstrated that the obesity associated chronic low-grade tissue inflammation and oxidative stress is crucial factors in the initiation, propagation, and development of these metabolic disorders. Disruption in the normal functioning of the immune system and its interaction with host tissue cells makes it difficult to treat these diseases. Macrophages play critical roles in the development of insulin resistance and tissue inflammation, particularly through a unique shift in polarized activation status from an anti-inflammatory M2 function in lean adipose tissues to proinflammatory M1 activation in adipose tissues of obese individuals. Compelling evidence demonstrated the significance of microRNAs as important regulators in the immune system network. Our recent research has demonstrated that microRNA-223 is a crucial regulator of obesity associated insulin resistance through regulation of macrophage polarization in adipose tissue. This review highlights the importance of various microRNAs and their roles played in the polarization of macrophages which could be targeted for development of new therapeutic strategies to treat obesity associated diseases.