MicroRNAs and Smooth Muscle Cells Phenotypic Switching in PAH
Dongqing Guo, Lida Wu and Yuchun Gu*
Molecular Pharmacology Laboratory, Institute of Molecular Medicine, Peking University, Beijing, China
- *Corresponding Author:
- Yuchun Gu
Molecular Pharmacology Laboratory
Institute of Molecular Medicine
Peking University, Beijing, 100871, China
E-mail: [email protected]
Received date: December 30, 2013; Accepted date: January 21, 2014; Published date: January 24, 2014
Citation: Guo D, Wu L, Gu Y (2014) MicroRNAs and Smooth Muscle Cells Phenotypic Switching in PAH. J Pulm Respir Med 4:168. doi:10.4172/2161-105X.1000168
Copyright: © 2014 Guo D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Smooth muscle cells undergo a switching from contractile phenotype to synthetic phenotype in pulmonary hypertension characterized by excessive proliferation and migration of smooth muscle cells. MicroRNAs are small noncoding RNAs that can negatively regulate gene expression by directly binding with the 3’-UTR of mRNA. Numerous microRNAs have been reported to modulate the smooth muscle cells phenotypic switching and been urged to become possible therapeutic targets for pulmonary hypertension. This review will focus on the roles of microRNAs in regulating smooth muscle cellular phenotypic switching in PAH.