MicroRNAs as a Potential Target for Cancer Therapy
Received Date: May 16, 2018 / Accepted Date: Jun 19, 2018 / Published Date: Jun 21, 2018
MicroRNAs (miRNAs) are evolutionary conserved small non-coding RNAs that negatively regulate gene expression by several mechanisms. Deregulation in expression of miRNAs has been reported in the pathogenesis of cancer. Accordingly, studies identified down regulation in the expression of miRNAs having tumor suppressor role and up-regulation in the expression of oncogenic miRNAs in different types of cancer. In response to these observations currently there are ongoing efforts to develop safe and effective miRNA-based therapeutics in the hope of fighting against cancer. This paper aimed at reviewing the role of miRNAs in tumorigenesis, and strategies for therapeutic targeting of miRNAs in cancer.
Keywords: MicroRNA; Tumor; Novel target; Cancer therapy; Tumorigenesis; Tumor suppressor
Citation: Mekuria AN, Abdi AD, Mishore KM (2018) MicroRNAs as a Potential Target for Cancer Therapy. J Cancer Sci Ther 10:152-161. Doi: 10.4172/1948-5956.1000535
Copyright: © 2018 Mekuria AN, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Select your language of interest to view the total content in your interested language
Share This Article
April 20-21, 2020 Berlin, Germany
- Total views: 3029
- [From(publication date): 0-2018 - Dec 08, 2019]
- Breakdown by view type
- HTML page views: 2874
- PDF downloads: 155