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ISSN: 1948-5956

Journal of Cancer Science & Therapy
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  • Review Article   
  • J Cancer Sci Ther/Vol.10.6 152(2018),
  • DOI: 10.4172/1948-5956.1000535

MicroRNAs as a Potential Target for Cancer Therapy

Abraham Nigussie Mekuria1*, Abraham Degaga Abdi1 and Kirubel Minsamo Mishore2
1Department of Pharmacology, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia
2Department of Clinical Pharmacy, School of Pharmacy, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia
*Corresponding Author : Abraham Nigussie Mekuria, PHD student in Pharmacology, Department of Pharmacology, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia, Tel: +251-115-152753, Email: [email protected]

Received Date: May 16, 2018 / Accepted Date: Jun 19, 2018 / Published Date: Jun 21, 2018

Abstract

MicroRNAs (miRNAs) are evolutionary conserved small non-coding RNAs that negatively regulate gene expression by several mechanisms. Deregulation in expression of miRNAs has been reported in the pathogenesis of cancer. Accordingly, studies identified down regulation in the expression of miRNAs having tumor suppressor role and up-regulation in the expression of oncogenic miRNAs in different types of cancer. In response to these observations currently there are ongoing efforts to develop safe and effective miRNA-based therapeutics in the hope of fighting against cancer. This paper aimed at reviewing the role of miRNAs in tumorigenesis, and strategies for therapeutic targeting of miRNAs in cancer.

Keywords: MicroRNA; Tumor; Novel target; Cancer therapy; Tumorigenesis; Tumor suppressor

Citation: Mekuria AN, Abdi AD, Mishore KM (2018) MicroRNAs as a Potential Target for Cancer Therapy. J Cancer Sci Ther 10:152-161. Doi: 10.4172/1948-5956.1000535

Copyright: © 2018 Mekuria AN, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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