alexa MicroRNAs in Prostate Cancer: Small RNAs with Big Roles
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

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Review Article

MicroRNAs in Prostate Cancer: Small RNAs with Big Roles

Ping Mu1*, Su Deng2,3 and Xiaozhou Fan4
1Memorial Sloan Kettering Cancer Center, Human Oncology and Pathogenesis Program,1275 York Avenue, New York, NY, 10065, USA
2Memorial Sloan Kettering Cancer Center, Developmental Biology Program, 1275 York Avenue, New York, NY, 10065, USA
3Weill Cornell Graduate School of Medical Sciences of Cornell University, Physiology, Biophysics and System Biology Program, 1300 York Avenue, New York, NY, 10065, USA
4The University of Texas M. D. Anderson Cancer Center, Department of Immunology, Houston, TX 77030
Corresponding Author : Mu P
Memorial Sloan Kettering Cancer Center
Human Oncology and Pathogenesis Program
1275 York Avenue, New York, NY, 10065, USA
Tel: 646-888-2139
E-mail: [email protected]
Received February 16, 2015; Accepted March 30, 2015; Published April 05, 2015
Citation: Mu P, Deng S, Fan X (2015) MicroRNAs in Prostate Cancer: Small RNAs with Big Roles. J Clin Cell Immunol 6:315. doi: 10.4172/2155-9899.1000315
Copyright: © 2015 Mu P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression either by mediating translational repression or reducing the stability of a target mRNA. Deregulated expression of miRNAs is a common feature of human cancers and a growing body of evidence demonstrates the role of miRNAs as either oncogenes or tumor suppressors. Many miRNAs have been reported to be associated with the pathogenesis of primary prostate cancer (PCa) and the development of castration resistant prostate cancer (CRPC). PCa is the most common cancer and second leading cause of cancer death in American men. Although patients with primary PCa can be treated with chemotherapy and hormone therapy, many of them will develop resistance to conventional therapies and progress to a more sever condition called CRPC, which remains one of the most difficult cancers to treat. Since emerging evidence suggests miRNAs’ significant roles in the tumorigenesis of primary PCa and CRPC, the potential of using miRNAs as drug targets and biomarkers for primary PCa and CRPC has been gaining more attention. The aim of this review is to summarize recent studies on the involvements and mechanisms of the actions of several miRNAs in the development and progression of primary PCa and CRPC. Additionally, the potentail applications of using miRNAs as biomarkers and drug targets are briefly discussed.

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