Microscopic Colitis as a Diagnosis to Consider by Clinicians and Pathologists Together: A Case Series and Review of Literature
|Tuttolomondo A1#, Di Raimondo D1*#, Orlando E2#, Della Corte V1, Bongiovanni L1, Portelli F2 and Pinto A1|
|1Internal Medicine and Cardioangiology Ward, Dipartimento Biomedico di Medicina Interna e Specialistica (Di.Bi.M.I.S), University of Palermo, Italy|
|2Human Pathology Section, Department of Health Sciences, University of Palermo, Italy|
|#These authors equally contributed to the manuscript|
|*Corresponding Author :||Domenico Di Raimondo
UOC di Medicina Interna e Cardioangiologia
Dipartimento Biomedico di Medicina Internae
Specialistica Università degli Studi di Palermo, ITALY
E-mail: [email protected]
|Received: December 23, 2015 Accepted: February 02, 2016 Published: February 05, 2016|
|Citation: Tuttolomondo A, Di Raimondo D, Orlando E, Della Corte V, Bongiovanni L, et al., (2016) Microscopic Colitis as a Diagnosis to Consider by Clinicians and Pathologists Together: A Case Series and Review of Literature. J Clin Cell Immunol 7:389. doi:10.4172/2155-9899.1000389|
|Copyright: © 2016 Tuttolomondo A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
Background: Microscopic colitis is a term used to define some clinical-pathological entities characterized by chronic watery diarrhea, normal radiological and endoscopic appearance, and microscopic abnormalities.
Aim: In this article we report a personal case series of microscopic colitis in patients with different age and sex and symptomatic seriousness to better represent the heterogeneous clinical presentation of this type of disease, and a review of available literature data.
Method: A definitive diagnosis of microscopic colitis is only possible by histological analysis. Specific histopathological findings, such as morphologically mild or moderate inflammation in the lamina propria, combined with either thickening of the sub-epithelial collagenous or lymphocytic attack on the surface epithelium, can be used to further classify these clinical entities as collagenous colitis (CC), lymphocytic colitis (LC), or other conditions.
Result: We presented a review of the most recents studies about microscopic colitis and we presented a case serie of four lymphocitic colitis and one collagenous colitis in patients with different age and sex and symptomatic seriousness to better represent the heterogeneous clinical presentation of this type of disease, and we also performed a brief review of available literature data analyzing epidemiology, pathogenesis, clinical presentation and therapy strategies of these group of colitis.
Discussion: Clinicians should be able to provide elements of clinical suspicion to pathologists that could justify more specific histological evaluation that includes the assessment of the number of intraepithelial cells (IEL), and the thickness of the band of tissue collagen.