alexa Microvesicles as Biomarkers in Diabetes, Obesity and Non-Alcoholic Fatty Liver Disease: Current Knowledge and Future Directions | OMICS International | Abstract
ISSN: 2165-8048

Internal Medicine: Open Access
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Review Article

Microvesicles as Biomarkers in Diabetes, Obesity and Non-Alcoholic Fatty Liver Disease: Current Knowledge and Future Directions

Joshua Welsh*, Judith Holloway and Nicola Englyst
Institute of Developmental Sciences (MPT887), University of Southampton Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
*Corresponding Author : Joshua Welsh
Institute of Developmental Sciences (MPT887)
University of Southampton Southampton General Hospital
Tremona Road, Southampton SO16 6YD, UK
Tel: 023 8120 6925;
E-mail: [email protected]
Received September 12, 2014; Accepted October 22, 2014; Published October 29, 2014
Citation: Welsh J, Holloway J, Englyst N (2014) Microvesicles as Biomarkers in Diabetes, Obesity and Non-Alcoholic Fatty Liver Disease:Current Knowledge and Future Directions. Intern Med S6:009. doi:10.4172/2165-8048.S6-009
Copyright: © 2014 Welsh J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

NAFLD is the most common chronic liver disease, frequently associated with diabetes. Both of these insulin resistant states have increased cardiovascular risk factors associated, and a prevalent cause of mortality in these diseases. Microvesicles are heterogonously sized, phospholipid rich spheres released by cells upon activation and apoptosis. Evidence is continuing to accumulate of microvesicles being not only markers of disease severity but as also having a functional role in the pathophysiology of disease progression.

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