Migraine in Patients with Metabolic Syndrome: Is there a Relationship to Leptin?Sherifa A Hamed1*, Manal E Ezz-El-Deen2 and Madleen A Abdou3
- *Corresponding Author:
- Sherifa Ahmed Hamed
Department of Neurology and Psychiatry
Assiut University Hospital, Assiut, Egypt, P.O.Box 71516
Tel: +2 01115324560
Fax: +2 088 2333327, +2 088 2332278
Email: [email protected]
Received date: May 08, 2012; Accepted date: July 07, 2012; Published date: July 09, 2012
Citation: Hamed SA, Ezz-El-Deen ME, Abdou MA (2012) Migraine in Patients with Metabolic Syndrome: Is there a Relationship to Leptin? Metabolomics 2:114. doi: 10.4172/2153-0769.1000114
Copyright: © 2012 Hamed SA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Previous studies have reported association of migraine and metabolic syndrome (MS) and between MS and
leptin (a protein product of the obesity gene). This study aimed to determine whether there is a link between MS and its components, leptin and migraine and its covariates (frequency and duration), as data regarding this relationship are still sparse or even controversial. This study included 60 patients with MS and comorbid migraine with mean age of 47.83±7.31 years. Demographic, anthropometric, clinical and lab characteristics were identified. Serum leptin concentrations were also measured. Nearly 58.33% had episodic migraine (MoA=44.64%, MA=16.6%), 35% had chronic migraine and 6.67% had tension type headache (TTH). Obesity, type 2 diabetes mellitus and hypertension and were reported in all patients, of them 80% had hypertriglyceridemia and/or dyslipidemia, 81.67% had insulin resistance (IR) and 58.33% hyperleptinemia. Compared to patients with TTH, patients with migraine had higher measurements for BMI (39.01 ± 6.05), WC (P = 0.058), poor glycemic control (8.11 ± 1.22), SBP (P = 0.052), DBP (P = 0.050) and serum levels of LDL-c (P = 0.0001), fasting insulin (P = 0.0001) and leptin (P = 0.0001). Leptin concentrations were found to
be positively correlated with BMI (r = 0.547, P = 0.008), WC (r = 0.445, P = 0.002), HbA1c (r = 0.656, P = 0.001) and fasting insulin (r = 0.613, P = 0.008). The logistic regression to model leptin and headache parameters (frequency and duration) after adjusting age and sex and leptin levels, were found to correlate with BMI, WC and fasting insulin) but this relationship disappeared after adjustment of these covariates. We conclude that comorbid migraine with MS is related to obesity (total body obesity and abdominal adiposity) and insulin abnormalities after adjustment of other covariates.