alexa Migration Stimulating Factor (MSF): A Novel Biomarker of Breast Cancer Progression
ISSN: 2161-1025

Translational Medicine
Open Access

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Research Article

Migration Stimulating Factor (MSF): A Novel Biomarker of Breast Cancer Progression

Stéphane Perrier1, Anne-Marie Woolston1, Colin A Purdie2, Syed Kazmi3, Paul E Preece3, Kevin J Davey1, Seth L Schor1,4 and Ana M Schor1,4,5*

1Unit of Cell and Molecular Biology, Dental School, University of Dundee, Dundee, DD1 4HR, UK

2Department of Pathology, Nine wells Hospital & Medical School, University of Dundee, Dundee DD1 9SY, UK

3Department of Surgery, Nine wells Hospital & Medical School, University of Dundee, Dundee DD1 9SY, UK.

4Bio-Engineering Units, Fulton Building, EPM, College of Art, Science and Engineering, University Dundee, Dundee DD1 4HN, UK

5Bio-Engineering Unit, Fulton Building, EPM, College of Art, Science and Engineering, University of Dundee, Dundee DD1 4HN, UK

*Corresponding Author:
Ana M Schor
Bio-Engineering Unit, Fulton Building, EPM
College of Art, Science and Engineering
University of Dundee, Dundee DD1 4HN, UK
Tel: +44 (0)1382 388423
Fax: +44 (0)1382 384389
Email:[email protected]

Received Date: November 13, 2011; Accepted Date: February 20, 2012; Published Date: February 22, 2012

Citation: Perrier S, Woolston A, Purdie CA, Kazmi S, Preece PE, et al. (2012) Migration Stimulating Factor (MSF): A Novel Biomarker of Breast Cancer Progression. Translational Medic S1:003. doi:10.4172/2161-1025.S1-003

Copyright: © 2012 Perrier S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Migration Stimulating Factor (MSF) is a novel oncofetal biomarker previously identified in a number of human tumours. The aim of this study was to evaluate the possible association between MSF expression and disease progression in breast cancer. Archival breast tissues examined included malignant tumours (T; n=23), benign tumours or pathologies (B; n=8) and histologically normal breast from either reduction mammoplasties (NB; n=19) or from tumour patients (NB-T; n=18). Sections were stained with MSF-specific antibodies and assessed by consensus of 3-4 independent observers in terms of various MSF indices, which represented overall, epithelial and stromal MSF expression. MSF was heterogeneously expressed by epithelial and stromal cells, with significant inter-group quantitative differences in the sequence NB

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