alexa Miktoarm Star Micelles Containing Curcumin Reduce Cell Viability of Sensitized Glioblastoma
ISSN: 2155-983X

Journal of Nanomedicine & Biotherapeutic Discovery
Open Access

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Research Article

Miktoarm Star Micelles Containing Curcumin Reduce Cell Viability of Sensitized Glioblastoma

Ghareb M Soliman1,2,3#, Anjali Sharma2, Yiming Cui1, Rishi Sharma2, Ashok Kakkar2*# and Dusica Maysinger1*#

1Department of Pharmacology and Therapeutics, McGill University, Canada

2Department of Chemistry, McGill University, Canada

3Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Egypt

#Author contributed equally

*Corresponding Author:
Ashok Kakkar
Department of Chemistry
McGill University, Canada
Tel: +1-514-398-6912
Fax: +1-514-398-3797
E-mail: [email protected]


Dusica Maysinger
Department of Pharmacology and Therapeutics
McGill University, Canada
Tel: +1-514-398-1264
Fax: +1-514-398-6690
E-mail: [email protected]

Received Date: March 07, 2014; Accepted Date: April 07, 2014; Published Date: April 09, 2014

Citation: Soliman GM, Sharma A, Cui Y, Sharma R, Kakkar A, et al. (2014) Miktoarm Star Micelles Containing Curcumin Reduce Cell Viability of Sensitized Glioblastoma. J Nanomedine Biotherapeutic Discov 4:124. doi: 10.4172/2155-983X.1000124

Copyright: © 2014 Soliman GM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Glioblastoma multiforme (GBM) is the most common and lethal primary intracranial tumor in humans. Monotherapeutic interventions have not been successful. The objective of the current studies was to establish the effective combination therapy consisting of pifitrin as a sensitizer, and curcumin as therapeutic incorporated into miktoarm micelles. A2B type miktoarm stars were prepared using a combination of click chemistry with ring opening polymerization on a core with orthogonal functionalities. These self-assemble into spherical micelles with hydrophobic core and hydrophilic corona structure. Micellar delivery systems for curcumin based on these miktoarm star polymers were prepared, characterized and tested on cultures sensitized with pifitrin. The results show that: (1) pifitrin and temozolamide in combination with curcumin cause significant cell death compared with the individual therapeutics (incorporated or not in micelles), and (2) repeated exposure to the same treatments is necessary to fully prevent a re-growth of glioblastoma cells both in 2D and 3D cultures. Although the incorporation of curcumin into A2B star polymer micelles did not increase the extent of cell death compared with curcumin alone, the advantage of micelles is that they significantly increase the aqueous solubility of curcumin and sustain its release; this will likely reduce the frequency of its administration required to be effective in vivo. A2B miktoarm polymers could be a new viable delivery system for curcumin and other anticancer drugs with similar limitations.

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