Millimeter Wave and Drug Induced Modulation of the Immune System -Application in Cancer ImmunotherapyMahendra K. Logani*, Mahendra K. Bhopale and Marvin C. Ziskin
Center for Biomedical Physics, Temple University School of Medicine, USA
- *Corresponding Author:
- Dr. Mahendra K. Logani
Center for Biomedical Physics
Temple University School of Medicine
3420 North Broad Street, Philadelphia, Pa 19140, USA
Tel: (215) 707-3321
Fax: (215) 707-4324
E-mail: [email protected]
Received date: October 29, 2011; Accepted date: November 23, 2011; Published date: November 25, 2011
Citation: Logani MK, Bhopale MK, Ziskin MC (2011) Millimeter Wave and Drug Induced Modulation of the Immune System -Application in Cancer Immunotherapy. J Cell Sci Ther S5:002. doi: 10.4172/2157-7013.S5-002
Copyright: © 2011 Logani MK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
In recent years several approaches have been used for the treatment of cancer. These include surgery, chemotherapy, radiotherapy, and immunotherapy. Immunotherapy includes systemic administration of cytokines, adaptive transfer of activated T cells, NK cells, dendritic cells and macrophages. Immunotherapy is used to stimulate and train the patient’s immune system to fight against cancer. However, this approach alone is not sufficient. Therefore, a combination of immunotherapy with conventional chemo- and radiation therapy is commonly used for the treatment of cancer. But systemic administration of cytokines, such as interferons and interleukins, commonly used for immunotherapy, have their own toxic side effects that can be life threatening to many patients. In this article, we have reviewed the current knowledge of the effects of millimeter wave therapy (MMWT) on the immune system. MMWT, an alternative and complementary modality of treatment, is widely used for the treatment of cancer and many other diseases in Russia and several East European countries. However, it is virtually unknown to Western physicians. Our experimental studies have shown that MMWT when used in combination with chemotherapy protects the immune system from the toxicity of chemotherapy without introducing any additional toxicity of its own. Furthermore, our studies have shown that the combined millimeter wave- and chemotherapy can reduce the tumor metastasis, and tumor resistance to chemotherapeutic drugs. Thus combined therapy using MMWT provides a promising new strategy for the treatment of cancer.