miR-146a Influences Energy Metabolism, Cell Differentiation and Innate ImmunityJessica M Huszar and Christopher J Payne*
Departments of Pediatrics and OB/GYN, Northwestern University Feinberg School of Medicine, Human Molecular Genetics Program, Ann & Robert H. Lurie Children’s Hospital of Chicago Research Center, Chicago, Illinois 60611, USA
- *Corresponding Author:
- Christopher J Payne
Ann & Robert H. Lurie Children’s Hospital of Chicago Research Center
Chicago, IL 60611 USA
Tel: +1 773 755 6316
Fax: +1 773 755 6593
E-mail: [email protected]
Received date: June 26, 2013; Accepted date: July 27, 2013; Published date: August 03, 2013
Citation: Huszar JM, Payne CJ (2013) miR-146a Influences Energy Metabolism, Cell Differentiation and Innate Immunity. Metabolomics 3:119. doi:10.4172/2153-0769.1000119
Copyright: © 2013 Huszar JM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
MicroRNAs play key regulatory roles in many different biological processes, including development, differentiation, homeostasis and inflammation. The latest version of miRBase lists over 1100 distinct microRNA sequences in mice and over 1800 in humans. One pair of mature microRNAs whose 3’ regions differ by only 2 nucleotides, miR-146a and miR- 146b, is involved in metabolism, differentiation and immunity. NF-κB directly induces miR-146a, while both miR-146a and miR-146b target NF-κB pathway components interleukin-1 receptor-associated kinase 1 (Irak1) and tumor necrosis factor receptor-associated factor-6 (Traf6) for repression. Inhibition of miR-146a increases glucose-stimulated insulin secretion and promotes differentiation of mouse spermatogonia. Muscle-specific inactivation of mediator complex subunit 1 (Med1), another miR-146a target, enhances insulin sensitivity and improves glucose tolerance in mice. This review highlights the role of miR-146a in metabolic regulation, hematopoietic and spermatogenic differentiation, and induction of the immune response.