alexa Mitochondria And Cancer: The Warburg Fact | OMICS International | Abstract
ISSN: 2167-7700

Chemotherapy: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Mitochondria And Cancer: The Warburg Fact

Albert M Kroon and Jan-Willem Taanman*

Department of Clinical Neurosciences, Institute of Neurology, University College London, UK

*Corresponding Author:
Jan-Willem Taanman
Department of Clinical Neurosciences
Institute of Neurology, University College London
Royal Free Campus, Rowland Hill Street, London, NW3 2PF, UK
Tel: +44 20 7794 0500
Fax: +44 20 7472 6829
E-mail: [email protected]

Received date: June 04, 2014; Accepted date: July 01, 2014; Published date: July 04, 2014

Citation: Kroon AM, Taanman JW (2014) Mitochondria and Cancer: The Warburg Fact. Chemotherapy 3:134. doi:10.4172/2167-7700.1000134

Copyright: © 2014 Kroon AM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Mitochondria play a key role in the energy generation of cells. Here, we reassess the opportunities to fight cancer by manipulating the expression of mitochondrial DNA (mtDNA). The mtDNA encodes 13 polypeptides that are all critical for oxidative phosphorylation. Most cancers, if not all, use glycolysis as main bioenergetic pathway, despite the presence of oxygen. This is known as the Warburg effect and leads to disturbance of the mitocytoplasmic energy balance. Cytosolic ATP levels are kept high by the increased glycolysis, limiting the demand for ATP from mitochondria. The restricted ADP-ATP exchange across the mitochondrial membranes results in a high ATP/ADP ratio within the organelles and a high mitochondrial membrane potential. Together, these increase the cancer cell’s resistance to apoptosis. Although the increased glycolysis may enhance the survival of cancer cells, several lines of evidence suggest that mitochondrial activity remains indispensable for proliferation. Specific inhibition of mitochondrial protein synthesis, e.g. with doxycycline, results in a mitonuclear protein imbalance, decreasing the apoptotic threshold and preventing proliferation of various cancer types in vivo. The anti-cancer effects are achieved at serum levels that are present in patients treated with the antibiotic to combat infections. There is good evidence to consider further clinical investigations with doxycycline to substantiate its beneficial effects on cancer.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

kactakapaniyor.com

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

Taktube

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

porn sex

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

Gaziantep Escort

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

sikiş

[email protected]

1-702-714-7001Extn: 9037

instafollowers

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

mp3 indir

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

putlockers

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

seks

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version