alexa Mitogen-Activated Protein Kinase (MAPK) Signaling Pathw
ISSN: 2329-8936

Transcriptomics: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Short Communication

Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway and Mammalian Cells

Waneene C Dorsey*
Molecular Toxicology, Grambling State University, Grambling, USA
Corresponding Author : Waneene C Dorsey
Molecular Toxicology, Grambling State University
Grambling, LA 71245, USA
Tel: 3182742399
Fax: 3182743870
E-mail: [email protected]
Received September 10, 2015; Accepted November 10, 2015; Published November 13, 2015
Citation:Dorsey WC (2015) Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway and Mammalian Cells. Transcriptomics 3:116. doi:10.4172/2329- 8936.1000116
Copyright: © 2015 Dorsey WC. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at Pubmed, Scholar Google


The mitogen-activated protein kinase (MAPK) pathway has been implicated as a key signaling system that mediates extracellular signals through a cascade of phosphorylation in mammalian cells. There are three distinct tiers in the MAPK pathway that are stimulated by different stress signals, ERK, JNK, and p38. Identifying cell signaling molecules as a response to stress is of extreme importance, since signal transduction provides the necessary link between a stimulus from the external environment of a cell and the events that occur among its intracellular components. Modulation of biomolecules in the MAPK family is a key mechanism of action and has the potential to cause cell cycle progression, proliferation, and differentiation. However, the onset of cancer is influenced by mutated regulatory genes. Therefore, when gene mutations occur, their products interact with biomolecules of the MAPK pathway. This interaction cause molecular events such as tumorigenesis to manifest.

Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version