alexa Mitogen-Activated Protein Kinase (MAPK) Signaling Pathw
ISSN: 2329-8936

Transcriptomics: Open Access
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Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway and Mammalian Cells

Waneene C Dorsey*
Molecular Toxicology, Grambling State University, Grambling, USA
Corresponding Author : Waneene C Dorsey
Molecular Toxicology, Grambling State University
Grambling, LA 71245, USA
Tel: 3182742399
Fax: 3182743870
E-mail: [email protected]
Received September 10, 2015; Accepted November 10, 2015; Published November 13, 2015
Citation:Dorsey WC (2015) Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway and Mammalian Cells. Transcriptomics 3:116. doi:10.4172/2329- 8936.1000116
Copyright: © 2015 Dorsey WC. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

The mitogen-activated protein kinase (MAPK) pathway has been implicated as a key signaling system that mediates extracellular signals through a cascade of phosphorylation in mammalian cells. There are three distinct tiers in the MAPK pathway that are stimulated by different stress signals, ERK, JNK, and p38. Identifying cell signaling molecules as a response to stress is of extreme importance, since signal transduction provides the necessary link between a stimulus from the external environment of a cell and the events that occur among its intracellular components. Modulation of biomolecules in the MAPK family is a key mechanism of action and has the potential to cause cell cycle progression, proliferation, and differentiation. However, the onset of cancer is influenced by mutated regulatory genes. Therefore, when gene mutations occur, their products interact with biomolecules of the MAPK pathway. This interaction cause molecular events such as tumorigenesis to manifest.

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