alexa MK615, A Compound Extract from the Japanese Apricot ?Prunus mume? Inhibits In vitro Cell Growth and Interleukin-8 Expression in Non-small Cell Lung Cancer Cells | Abstract
ISSN: 1948-5956

Journal of Cancer Science & Therapy
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Research Article

MK615, A Compound Extract from the Japanese Apricot ?Prunus mume? Inhibits In vitro Cell Growth and Interleukin-8 Expression in Non-small Cell Lung Cancer Cells

Noriaki Sunaga1*, Katsuya Hiraishi2, Tamotsu Ishizuka1, Kyoichi Kaira1, Yasuki Iwasaki1, Fumie Jimma2, Masakazu Adachi2and Masatomo Mori1
1Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma 371-8511, Japan
2Adabio Co., Ltd., 21-2 Kenzaki-machi, Takasaki, Gunma 370-0883, Japan
Corresponding Author : Noriaki Sunaga, MD
Department of Medicine and Molecular Science
Gunma University School of Medicine
3-39-15, Showa-machi, Maebashi
Gunma 371-8511, Japan
Tel: +81-27-220-8136
Fax: +81-27-220-8136
E-mail: [email protected]
Received February 28, 2012; Accepted March 09, 2012; Published March 12, 2012
Citation: Sunaga N, Hiraishi K, Ishizuka T, Kaira K, Iwasaki Y, et al. (2011) MK615, A Compound Extract from the Japanese Apricot “Prunus mume” Inhibits In vitro Cell Growth and Interleukin-8 Expression in Non-small Cell Lung Cancer Cells. J Cancer Sci Ther S11:002. doi:10.4172/1948-5956.S11-002
Copyright: © 2011 Sunaga N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

The Japanese apricot “Prunus mume,” which is also known as the Ume fruit in Japan, is a centuries-old traditional Japanese medicine, and it is a commonly consumed food. MK615, a compound extract from Ume fruits, has been shown to have anti-tumor and anti-inflammatory effects. In this study, we assessed the effects of MK615 on the in vitro growth of nine non-small cell lung cancer (NSCLC) cell lines and the HBEC4 immortalized bronchial epithelial cell line. While MK615 inhibited the in vitro cell growth of the majority of the NSCLC cell lines, the growthinhibitory effects varied among the cell lines, and some cell lines exhibited MK615 resistance. In the H1299 and H157 NSCLC cell lines that are highly sensitive to MK615, the induction of autophagy was observed after MK615 treatment. In addition, cell-cycle analysis showed that MK615 increased the proportion of cells in the G0-G1 phase in H1299 and H157 cells. In H1792 cells that overexpress IL-8, MK615 down-regulated IL-8 expression at the mRNA and protein levels in a dose-dependent manner. These results suggest that MK615 has multiple anti-tumor activities including the inhibition of cell proliferation, autophagy induction, G0-G1 cell cycle arrest and the downregulation of IL-8 expression in NSCLC cells.

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