alexa Model Roles of the Hypothalamo-Neurohypophysial System in Neuroscience Study
ISSN: 2167-0501

Biochemistry & Pharmacology: Open Access
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Review Article

Model Roles of the Hypothalamo-Neurohypophysial System in Neuroscience Study

Dan Hou#, Feng Jin#, Jiaoyan Li#, Jie Lian#, Mingyang Liu#, Xinna Liu#, Yanan Xu#, Chaoyu Zhang#, Chen Zhao#, Shuwei Jia#, Runsheng Jiao#, Xiaoyu Liu#, Xiaoran Wang#, Ying Zhang# and Yu-Feng Wang*

Department of Physiology, Harbin Medical University, Harbin, China

#All authors contributed equally

*Corresponding Author:
Yu-Feng Wang
Department of Physiology
School of Basic Medical Sciences Harbin Medical University
157 Baojian Rd, Nangang, Harbin
Heilongjiang 150081, China
Tel: +86-451-86674538
Fax: +86-451-86674538
E-mail: [email protected]

Received date: May 19, 2016; Accepted date: June 16, 2016; Published date: June 20, 2016

Citation: Hou D, Jin F, Li J, Lian J, Liu M, et al. (2016) Model Roles of the Hypothalamo-Neurohypophysial System in Neuroscience Study. Biochem Pharmacol (Los Angel) 5:211. doi:10.4172/2167-0501.1000211

Copyright: © 2016 Hou D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Studies on the Hypothalamo-Neurohypophysial System (HNS) have played a pivotal role in establishing the fundamental principles of neuroscience. Examples include the identification of excitation-secretion coupling, coexistence of peptides-containing large dense core vesicles with classical neurotransmitters, neuronal-glial interactions, functionsassociated morphological plasticity, and domain-specific regulation of the secretory activity, etc. Moreover, mechanisms underlying the secretion by the HNS and functions of neuropeptides oxytocin and vasopressin remain the central topic of the neuroendocrine society, novel findings of which keep substantiating the model role of this system. Nevertheless, challenges are still severe in this study field, such as extrahypothalamic connections of the HNS, scaffolding and guiding roles of glial fibrillary acidic protein in astrocyte plasticity, cellular and molecular processes determining different firing patterns, the position of the HNS in neuroendocrine-immune network, and the nose-hypothalamic route that serves as a key mediator of drug effects on brain activity. Nowadays, translational studies of the HNS also become the prime time of researchers, such as vasopressin involvement in brain injury in ischemic stroke, and therapeutic potentials of oxytocin in lactation failure and its associated health issues. In this paper, we review these challenges in modern neuroscience studies on the HNS.


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