Model Tumor Pattern and Compare Treatment Effects Using Semiparametric Linear Mixed-Effects Models
- *Corresponding Author:
- Hua Liang
Department of Biostatistics and Computational Biology
University of Rochester Medical Center
Rochester, New York 14642, USA
E-mail: [email protected]
Received Date: May 15, 2013; Accepted Date: June 17, 2013; Published Date: June 21, 2013
Citation: Xia C, Wu J, Liang H (2013) Model Tumor Pattern and Compare Treatment Effects Using Semiparametric Linear Mixed-Effects Models. J Biomet Biostat 4:168. doi:10.4172/2155-6180.1000168
Copyright: © 2013 Xia C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
To analyze responses of solid tumor to treatments and to compare treatment effects with antitumor therapies, we applied semiparametric mixed-effects models to fit tumor volumes measured over a period. The population and individual nonparametric functions were approximated by smoothing spline. We also proposed an intuitive method for a comparison of the antitumor effects of two different treatments. Biological interpretation was also discussed.